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Results: 5
Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers.
BACKGROUND: Complex clusters of rearrangements are a challenge in interpretation of cancer genomes. Some clusters of rearrangements demarcate clear amplifications of driver oncogenes but others are less well understood. A...
Adult Age Distribution Aged Aged 80 and over Algorithms Breast Breast Neoplasms Carrier Proteins Chromosomes Human Pair 11 Chromosomes Human Pair 8 Cyclin D1 Datasets as Topic Female Gene Amplification Genetic Loci Genomics Humans Middle Aged Oncogenes Receptor Fibroblast Growth Factor Type 1 Translocation Genetic whole genome sequencing
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma.
Antonio Giuliano, Rebecca Swift, Callum Arthurs, Georgina Marote, Francesca Abramo, Jenny McKay, Calum Thomson, Mariana Beltran, Michael Millar, Simon Priestnall, Jane Dobson, Fernando Costantino-Casas, Terry Petrou, Imelda M McGonnell, Anthony J Davies, Malcolm Weetman, Oliver A Garden, John R Masters, Christopher Thrasivoulou, Aamir Ahmed
Sep 22, 2016
Animals Carcinoma Squamous Cell Cat Diseases Cats Cyclin D1 Gene Expression Regulation Neoplastic Hydrogen-Ion Concentration Matrix Metalloproteinase 7 Microtubule-Associated Proteins Mouth Neoplasms Neoplasm Proteins Proto-Oncogene Proteins c-myc ROC Curve Transcription Factors Wnt Proteins Wnt Signaling Pathway beta Catenin
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Evangelia K Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant D Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Y Warren, Shamith A Samarajiwa, Jason S Carroll, Sakari Vanharanta
Jul 09, 2022
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer.
UNLABELLED: Fenofibrate, an agonist of PPAR-alpha, in doses above 25 microM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an...
Animals Antineoplastic Agents Apoptosis Cell Line Tumor Cell Proliferation Cyclin D1 Dose-Response Relationship Drug Endometrial Neoplasms Female Fenofibrate Gene Expression Profiling Gene Expression Regulation Humans Methionine Adenosyltransferase Mice Mice Nude Neoplasm Transplantation Oligonucleotide Array Sequence Analysis PPAR alpha RNA Interference RNA Messenger Tretinoin