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Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...

Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine

Cytidine Deaminase DRUG METABOLISM Gemcitabine Pancreatic Adenosquamous Carcinoma Antimetabolites Antineoplastic Carcinoma Adenosquamous Chemotherapy Adjuvant Cytidine Deaminase Deoxycytidine Female Gene Expression Humans Immunohistochemistry Magnetic Resonance Imaging Middle Aged Pancreatic Neoplasms Recurrence Retreatment Tomography X-Ray Computed Treatment Outcome Gemcitabine

Spatial and temporal dissection of the genomic changes occurring during the evolution of human non-small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25 spatially distinct regions...

APOBEC-1 Deaminase Carcinogens Carcinoma Non-Small-Cell Lung Cytidine Deaminase evolution Molecular Gene Dosage Genetic Heterogeneity Genomic Instability Humans Lung Neoplasms Mutation Neoplasm Recurrence Local Prognosis Smoking Translocation Genetic Tumor Cells Cultured

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1...

Animals B-Lymphocytes Cytidine Deaminase Immunoglobulin Class Switching Immunoglobulin E Interleukin-4 Mice Mice Inbred BALB C Promoter Regions Genetic Transcription Genetic

Case report Medical and radiation oncology Cytidine Deaminase DRUG METABOLISM Gemcitabine Pancreatic Adenosquamous Carcinoma

APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer types. However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC...

Child Humans Child Preschool Apolipoproteins B Cytidine Deaminase Mutagenesis RNA Messenger APOBEC-1 Deaminase Intestine Small

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER...

Binding Sites Breast Neoplasms Cell Line Tumor Cell Proliferation Cytidine Cytidine Deaminase DNA DNA Damage DNA End-Joining Repair Deamination Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Humans Minor Histocompatibility Antigens Prognosis Protein Binding RNA Small Interfering Signal Transduction Survival Analysis Transcription Genetic Trefoil Factor-1 Tumor Suppressor Proteins

Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B...

Cell Line Cyclin-Dependent Kinase Inhibitor p21 Cytidine Deaminase Gene Expression Regulation Neoplastic HCT116 Cells Humans Immunoblotting Minor Histocompatibility Antigens Mutation Neoplasms RNA Interference Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Protein p53

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we...

APOBEC-1 Deaminase BRCA2 Protein Breast Neoplasms Cytidine Deaminase DNA Mutational Analysis Female Genes BRCA1 Genome-Wide Association Study High-Throughput Nucleotide Sequencing Humans Mutation

Adult Aged Case-Control Studies Cytidine Deaminase Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Minor Histocompatibility Antigens Neoplasms Norway Polymorphism Genetic Proteins Risk Factors White People

Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions...

AID/APOBECs Cancer Cytidine deamination DNA deamination human Hypermutation Kataegis S. cerevisiae Breast Neoplasms Cytidine Deaminase Female Humans Minor Histocompatibility Antigens Mutation Proteins

Case report Medical and radiation oncology Cytidine Deaminase DRUG METABOLISM Gemcitabine Pancreatic Adenosquamous Carcinoma

BACKGROUND:Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic...

DRUG METABOLISM Cytidine Deaminase Gemcitabine Pancreatic Adenosquamous Carcinoma

The gastrointestinal tract is colonized by trillions of commensal microorganisms that collectively form the microbiome and make essential contributions to organism homeostasis. The intestinal immune system must tolerate these...

B cells Antibodies intestinal immunity B-Lymphocytes Cells Cultured Cytidine Deaminase Cytokines Gastrointestinal Microbiome Humans Immunity Humoral Immunoglobulin A Immunoglobulin Class Switching Immunoglobulin G Intestines

Breast Neoplasms Cytidine Deaminase DNA Copy Number Variations Female Genetic Markers Genetic Predisposition to Disease Humans Minor Histocompatibility Antigens Mutagenesis Proteins Sequence Deletion

All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the...

aging Algorithms Cell Transformation Neoplastic Cytidine Deaminase DNA DNA Mutational Analysis Humans Models Genetic Mutagenesis Mutagenesis Insertional Mutagens Mutation Neoplasms Organ Specificity Reproducibility of Results Sequence Deletion Transcription Genetic