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Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon.
David Bernardo, Lydia Durant, Elizabeth R Mann, Elizabeth Bassity, Enrique Montalvillo, Ripple Man, Rakesh Vora, Durga Reddi, Fahri Bayiroglu, Luis Fernández-Salazar, Nick R English, Simon TC Peake, Jon Landy, Gui H Lee, George Malietzis, Yi Harn Siaw, Aravinth U Murugananthan, Phil Hendy, Eva Sánchez-Recio, Robin KS Phillips, Jose A Garrote, Paul Scott, Julian Parkhill, Malte Paulsen, Ailsa L Hart, Hafid O Al-Hassi, Eduardo Arranz, Alan W Walker, Simon R Carding, Stella C Knight
Sep 06, 2019
BACKGROUND & AIMS: Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103+ DC specialize in generating immune tolerance with the functionality of CD11b+/- subsets being...
AMOVA analysis of molecular variance CCL chemokine (C-C motif) ligand CCR chemokine (C-C motif) receptor CCR2 CFSE 5-carboxy fluorescein diacetate succinimidyl ester DC dendritic cells DL detection limit Dendritic Cells Distal colon FACS fluorescence-activated cell sorting FITC fluorescein isothiocyanate GI Gastrointestinal Human Gastrointestinal Tract IL Interleukin ILT3 Ig-like transcript 3 LPMC lamina propria mononuclear cells Microbiota Mφ macrophages PBMC peripheral blood mononuclear cells pcr polymerase chain reaction Proximal Colon RALDH2 retinaldehyde dehydrogenase type 2 SIRPα signal regulatory protein α SPB sodium phosphate buffer Treg regulatory T-cells mDC myeloid dendritic cell pDC plasmacytoid dendritic cell
Statistical Cerebrovascular Reactivity Signal Properties after Secondary Decompressive Craniectomy in Traumatic Brain Injury
Frederick A Zeiler, Marcel Aries, Manuel Cabeleira, Thomas A van Essen, Nino Stocchetti, David K Menon, Ivan Timofeev, Marek Czosnyka, Peter Smielewski, Peter Hutchinson, Ari Ercole, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Dec 20, 2019
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed to determine if the statistical properties of vascular reactivity metrics and slow-wave...
DC PRx TBI cerebrovascular reactivity Decompressive Craniectomy Adolescent Adult Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Decompressive Craniectomy Female Humans Intensive Care Units Intracranial Pressure Male Middle Aged Pilot Projects Prospective Studies Tomography X-Ray Computed Young Adult