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Results: 27
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Parimal Samir, Sannula Kesavardhana, Deanna M Patmore, Sebastien Gingras, RK Subbarao Malireddi, Rajendra Karki, Clifford S Guy, Benoit Briard, David E Place, Anannya Bhattacharya, Bhesh Raj Sharma, Amanda Nourse, Sharon V King, Aaron Pitre, Amanda R Burton, Stephane Pelletier, Richard J Gilbertson, Thirumala-Devi Kanneganti
Oct 25, 2019
Large-scale discovery of novel genetic causes of developmental disorders.
Deciphering Developmental Disorders Study
Feb 01, 2021
Despite three decades of successful, predominantly phenotype-driven discovery of the genetic causes of monogenic disorders, up to half of children with severe developmental disorders of probable genetic origin remain without a...
Adolescent Animals Carrier Proteins Child Child Preschool Chromosomal Proteins Non-Histone Chromosome Aberrations DEAD-box RNA Helicases DNA-Binding Proteins Developmental Disabilities Dynamin I Exome Female Gene Expression Regulation Developmental Genes Dominant Genome Human Guanine Nucleotide Exchange Factors Homeodomain Proteins Humans Infant Infant Newborn Male Mutation Missense Nerve Tissue Proteins Nuclear Proteins Parents Phosphoproteins Polycomb Repressive Complex 1 Protein Phosphatase 2 Protein Serine-Threonine Kinases Rare Diseases Repressor Proteins Transcription Factors Transposases United Kingdom Zebrafish
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies.
Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.
Nelly Sabbaghian, Amin Bahubeshi, Andrew Y Shuen, Peter A Kanetsky, Marc D Tischkowitz, Katherine L Nathanson, William D Foulkes
May 02, 2013
RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.
Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh T Ghanbarian, Guillem Portella, Shankar Balasubramanian
Jan 07, 2019
DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV.
Nyaradzai Sithole, Claire A Williams, Aisling M Vaughan, Julia C Kenyon, Andrew ML Lever
Sep 10, 2018
A4/A5 3′ splice site cluster DDX17/HIV-1 splicing factors Alternative Splicing Amino Acid Motifs Cell Line Tumor Cells Cultured DEAD-box RNA Helicases Gene Expression Regulation Viral Gene Knockdown Techniques HIV Infections HIV-1 Humans Protein Binding Protein Interaction Domains and Motifs RNA Splice Sites
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).
Emily V Wong, Wenxiang Cao, Judit Vörös, Monique Merchant, Yorgo Modis, David D Hackney, Ben Montpetit, Enrique M De La Cruz
Aug 09, 2017
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Michael C Chen, Ramreddy Tippana, Natalia A Demeshkina, Pierre Murat, Shankar Balasubramanian, Sua Myong, Adrian R Ferré-D'Amaré
Aug 03, 2018
Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can...
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.
Cherie Blenkiron, Leonard D Goldstein, Natalie P Thorne, Inmaculada Spiteri, Suet-Feung Chin, Mark J Dunning, Nuno L Barbosa-Morais, Andrew E Teschendorff, Andrew R Green, Ian O Ellis, Simon Tavaré, Carlos Caldas, Eric A Miska
Jun 14, 2011
The DDX6-4E-T interaction mediates translational repression and P-body assembly.
Anastasiia Kamenska, Clare Simpson, Caroline Vindry, Helen Broomhead, Marianne Bénard, Michèle Ernoult-Lange, Benjamin P Lee, Lorna W Harries, Dominique Weil, Nancy Standart
Jul 12, 2016
Amino Acid Sequence Binding Sites DEAD-box RNA Helicases DNA-Binding Proteins Eukaryotic Initiation Factor-4E Eukaryotic Initiation Factor-4G Gene Expression Regulation HEK293 Cells HeLa Cells Humans Nucleocytoplasmic Transport Proteins Protein Binding Protein Biosynthesis Protein Interaction Maps Proto-Oncogene Proteins RNA Small Interfering RNA-Binding Proteins Transcription Factors
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome.
Prevalence and architecture of de novo mutations in developmental disorders.
Deciphering Developmental Disorders Study
Feb 07, 2020
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing...
Adolescent Adult Autoantigens CDC2 Protein Kinase Casein Kinase II Child Chromosomal Proteins Non-Histone Cohort Studies DEAD-box RNA Helicases DNA-Binding Proteins Developmental Disabilities Exome Female Heredity Histone-Lysine N-Methyltransferase Homeodomain Proteins Humans Male Mi-2 Nucleosome Remodeling and Deacetylase Complex Middle Aged Mutation Myeloid-Lymphoid Leukemia Protein Nerve Tissue Proteins Parents Phenotype prevalence Protein Phosphatase 2C Repressor Proteins Sequence Analysis DNA Sex Characteristics Transcription Factors Young Adult ras GTPase-Activating Proteins
P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).
Emily V Wong, Wenxiang Cao, Judit Vörös, Monique Merchant, Yorgo Modis, David D Hackney, Ben Montpetit, Enrique M De La Cruz
Mar 03, 2016
Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases.
Members of the DEAD-box family of RNA helicases contribute to virtually every aspect of RNA metabolism, in organisms from all domains of life. Many of these helicases are constituents of multicomponent assemblies, and their...
Analytical Ultracentrifugation protein-protein interactions RNA helicase RNA-binding protein Regulator of Ribonuclease Activity A RhlB RraA SrmB X-ray crystallography Crystallography X-Ray DEAD-box RNA Helicases Endoribonucleases Escherichia coli Escherichia coli Proteins Models Molecular Protein Binding Protein Structure Quaternary Protein Structure Tertiary
Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.
Barbara Herdy, Clemens Mayer, Dhaval Varshney, Giovanni Marsico, Pierre Murat, Chris Taylor, Clive D'Santos, David Tannahill, Shankar Balasubramanian
Nov 16, 2018
DDX5 potentiates HIV-1 transcription as a co-factor of Tat.
BACKGROUND: HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently...
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.
Katsuhiko Hayashi, Susana M Chuva de Sousa Lopes, Masahiro Kaneda, Fuchou Tang, Petra Hajkova, Kaiqin Lao, Donal O'Carroll, Partha P Das, Alexander Tarakhovsky, Eric A Miska, M Azim Surani
Feb 15, 2021
BACKGROUND: MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells...
Animals Argonaute Proteins Cell Differentiation Cell Proliferation Cells Cultured DEAD-box RNA Helicases DNA Methylation Endoribonucleases Eukaryotic Initiation Factor-2 Female Gene Expression Regulation Germ Cells Inhibitor of Apoptosis Proteins Integrases Long Interspersed Nucleotide Elements Male Mice Mice Knockout MicroRNAs RNA Small Interfering Ribonuclease III Spermatogenesis Testis Ubiquitin-Protein Ligases
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Miller Huang, Jignesh Tailor, Qiqi Zhen, Aaron H Gillmor, Matthew L Miller, Holger Weishaupt, Justin Chen, Tina Zheng, Emily K Nash, Lauren K McHenry, Zhenyi An, Fubaiyang Ye, Yasuhiro Takashima, James Clarke, Harold Ayetey, Florence MG Cavalli, Betty Luu, Branden S Moriarity, Shirin Ilkhanizadeh, Lukas Chavez, Chunying Yu, Kathreena M Kurian, Thierry Magnaldo, Nicolas Sevenet, Philipp Koch, Steven M Pollard, Peter Dirks, Michael P Snyder, David A Largaespada, Yoon Jae Cho, Joanna J Phillips, Fredrik J Swartling, A Sorana Morrissy, Marcel Kool, Stefan M Pfister, Michael D Taylor, Austin Smith, William A Weiss
Jul 25, 2019
Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines...
SHH Human pluripotent stem cells Medulloblastoma neuroepithelial stem cells Animals Basal Cell Nevus Syndrome Brain Neoplasms Carcinogenesis DEAD-box RNA Helicases Disease Models Animal Genetic Engineering Genetic Predisposition to Disease Humans Medulloblastoma Mice Mice SCID N-Myc Proto-Oncogene Protein Neoplasm Proteins Neural Stem Cells Neuroepithelial Cells Patched-1 Receptor Pluripotent Stem Cells Stem Cell Transplantation Transplantation Heterologous
Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.
Accurate target recognition in transcript degradation is crucial for regulation of gene expression. In the fission yeast Schizosaccharomyces pombe, a number of meiotic transcripts are recognized by a YTH-family RNA-binding...
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