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James Darnell, Jr., 1973
The Rockefeller University
Jan 01, 0001
James E. Darnell, Jr. The origins of mRNA and the structure of the mammalian chromosome
Lecture delivered September 20, 1973
Posted with permission
Published by: Academic Press
2'-Alkynylnucleotides
Marius M Haugland, Afaf H El-Sagheer, Rachel J Porter, Javier Peña, Tom Brown, Edward A Anderson, Janet E Lovett
Jan 26, 2018
Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible...
Tissue-specific transcriptomes of Anisakis simplex (sensu stricto) and Anisakis pegreffii reveal potential molecular mechanisms involved in pathogenicity.
Serena Cavallero, Fabrizio Lombardo, Xiaopei Su, Marco Salvemini, Cinzia Cantacessi, Stefano D'Amelio
Feb 05, 2018
Background: Larval stages of the sibling species of parasitic nematodes Anisakis simplex sensu stricto (AS) and Anisakis pegreffii (AP) are responsible for a fish-borne zoonosis, known as anisakiasis, that humans acquire via the...
Repeat DNA-PAINT suppresses background and non-specific signals in optical nanoscopy.
Alexander H Clowsley, William T Kaufhold, Tobias Lutz, Anna Meletiou, Lorenzo Di Michele, Christian Soeller
Jan 21, 2021
Metagenomic analyses and genetic diversity of Tomato leaf curl Arusha virus affecting tomato plants in Kenya.
Edith Khamonya Avedi, Adedapo Olutola Adediji, Dora Chao Kilalo, Florence Mmogi Olubayo, Isaac Macharia, Elijah Miinda Ateka, Eunice Magoma Machuka, Josiah Musembi Mutuku
Jan 07, 2021
DNA damage, cellular senescence and organismal ageing
Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both...
De-fusing mitochondria defuses the mtDNA time-bomb.
Being uniparentally inherited and with a high mutation rate, mitochondrial DNA (mtDNA) should relentlessly acquire mutations, eventually destroying a species through “mutational meltdown”. Lieber et al. now show that...
Structural biology of multicomponent assemblies in DNA double-strand-break repair through non-homologous end joining.
Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.
Matthew D Hall, Matthew TG Holden, Pramot Srisomang, Weera Mahavanakul, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Kay Fountain, Julian Parkhill, Emma K Nickerson, Sharon J Peacock, Christophe Fraser
Nov 04, 2019
MRSA EPIDEMIOLOGY Global Health hospital infections human molecular epidemiology Adult Child Computational Biology Cross Infection DNA Bacterial Disease Outbreaks genetic variation Genome Bacterial Humans Methicillin-Resistant Staphylococcus aureus Phylogeny Polymorphism Single Nucleotide Staphylococcal Infections Thailand whole genome sequencing
ctDNA monitoring using patient-specific sequencing and integration of variant reads.
Jonathan CM Wan, Katrin Heider, Davina Gale, Suzanne Murphy, Eyal Fisher, Florent Mouliere, Andrea Ruiz-Valdepenas, Angela Santonja, James Morris, Dineika Chandrananda, Andrea Marshall, Andrew B Gill, Pui Ying Chan, Emily Barker, Gemma Young, Wendy N Cooper, Irena Hudecova, Francesco Marass, Richard Mair, Kevin M Brindle, Grant D Stewart, Jean E Abraham, Carlos Caldas, Doris M Rassl, Robert C Rintoul, Constantine Alifrangis, Mark R Middleton, Ferdia A Gallagher, Christine Parkinson, Amer Durrani, Ultan McDermott, Christopher G Smith, Charles Massie, Pippa G Corrie, Nitzan Rosenfeld
Jun 23, 2020
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume or residual disease, where plasma contains very few tumor-derived DNA...
Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster.
Alekos Simoni, Carla Siniscalchi, Yuk-Sang Chan, David S Huen, Steven Russell, Nikolai Windbichler, Andrea Crisanti
Mar 27, 2020
Selfish genes are DNA elements that increase their rate of genetic transmission at the expense of other genes in the genome and can therefore quickly spread within a population. It has been suggested that selfish elements could...
RNA proximity sequencing data and analysis pipeline from a human neuroblastoma nuclear transcriptome.
We have previously developed and described a method for measuring RNA co-locations within cells, called Proximity RNA-seq, which promises insights into RNA expression, processing, storage and translation. Here, we describe...
DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids.
Sebastian Canovas, Elena Ivanova, Raquel Romar, Soledad García-Martínez, Cristina Soriano-Úbeda, Francisco A García-Vázquez, Heba Saadeh, Simon Andrews, Gavin Kelsey, Pilar Coy
Jun 24, 2019
The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, suggesting...
Fratricide activity of MafB protein of N. meningitidis strain B16B6.
Jesús Arenas, Vincent de Maat, Laura Catón, Massis Krekorian, Juan Cruz Herrero, Flavio Ferrara, Jan Tommassen
May 11, 2020
BACKGROUND: Neisseria meningitidis is an inhabitant of the mucosal surfaces of the human nasopharynx. We recently demonstrated that the secreted meningococcal Two-partner secretion protein A (TpsA) is involved in interbacterial...
CTCF maintains regulatory homeostasis of cancer pathways.
Sarah J Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C Marioni, Duncan T Odom
Sep 20, 2018
CTCF Cancer Chromatin architecture chromatin state Hemizygosity Transcription Animals Breast Neoplasms CCCTC-Binding Factor Cell Line Chromatin DNA Neoplasm Enhancer Elements Genetic Female FIBROBLASTS Gene Expression Regulation Neoplastic Genome Hemizygote Homeostasis Humans Liver Neoplasms Experimental Mice Mice Inbred C57BL Mice Transgenic Protein Binding Signal Transduction Uterine Neoplasms
Epilepsy in adults with mitochondrial disease
Roger G Whittaker, Helen E Devine, Grainne S Gorman, Andrew M Schaefer, Rita Horvath, Yi Ng, Victoria Nesbitt, Nichola Z Lax, Robert McFarland, Mark O Cunningham, Robert W Taylor, Douglass M Turnbull
Mar 07, 2019
OBJECTIVE: The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. METHODS: We prospectively recruited a cohort of 182 consecutive adult patients attending a...
Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations.
Helen R Griffin, Angela Pyle, Emma L Blakely, Charlotte L Alston, Jennifer Duff, Gavin Hudson, Rita Horvath, Ian J Wilson, Mauro Santibanez-Koref, Robert W Taylor, Patrick F Chinnery
Mar 07, 2019
PURPOSE: Mitochondrial disorders are a common cause of inherited metabolic disease and can be due to mutations affecting mitochondrial DNA or nuclear DNA. The current diagnostic approach involves the targeted resequencing of...
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
Mar 21, 2019
BACKGROUND: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic...
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Nguyen Thuy Thuong Thuong, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Hoang Thanh Hai, Vu Thi Ngoc Ha, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
Sep 05, 2018
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates...
The Role of DNA Repair in Maintaining Mitochondrial DNA Stability.
Mitochondria are vital double-membrane organelles that act as a "powerhouse" inside the cell and have essential roles to maintain cellular functions, e.g., ATP production, iron-sulfur synthesis metabolism, and steroid synthesis....
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.
The vaccinia virus E3 protein is an important intracellular modulator of innate immunity that can be split into distinct halves. The C terminus contains a well defined dsRNA-binding domain, whereas the N terminus contains a...
Ancient goat genomes reveal mosaic domestication in the Fertile Crescent.
Kevin G Daly, Pierpaolo Maisano Delser, Victoria E Mullin, Amelie Scheu, Valeria Mattiangeli, Matthew D Teasdale, Andrew J Hare, Joachim Burger, Marta Pereira Verdugo, Matthew J Collins, Ron Kehati, Cevdet Merih Erek, Guy Bar-Oz, François Pompanon, Tristan Cumer, Canan Çakırlar, Azadeh Fatemeh Mohaseb, Delphine Decruyenaere, Hossein Davoudi, Özlem Çevik, Gary Rollefson, Jean-Denis Vigne, Roya Khazaeli, Homa Fathi, Sanaz Beizaee Doost, Roghayeh Rahimi Sorkhani, Ali Akbar Vahdati, Eberhard W Sauer, Hossein Azizi Kharanaghi, Sepideh Maziar, Boris Gasparian, Ron Pinhasi, Louise Martin, David Orton, Benjamin S Arbuckle, Norbert Benecke, Andrea Manica, Liora Kolska Horwitz, Marjan Mashkour, Daniel G Bradley
Nov 29, 2018
Current genetic data are equivocal as to whether goat domestication occurred multiple times or was a singular process. We generated genomic data from 83 ancient goats (51 with genome-wide coverage) from Paleolithic to Medieval...
Rapid sequencing of MRSA direct from clinical plates in a routine microbiology laboratory.
Beth Blane, Kathy E Raven, Danielle Leek, Nicholas Brown, Julian Parkhill, Sharon J Peacock
Apr 12, 2019
BACKGROUND: Routine sequencing of MRSA could bring about significant improvements to outbreak detection and investigation. Sequencing is commonly performed using DNA extracted from a pure culture, but overcoming the delay...
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