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Delivery and impact of the NHS Health Check in the first 8 years
Adam Martin, Catherine L Saunders, Emma Harte, Simon J Griffin, Calum MacLure, Jonathan Mant, Catherine Meads, Fiona M Walter, Juliet A Usher-Smith
May 02, 2018
BACKGROUND: Since 2009, all eligible persons in England have been entitled to an NHS Health Check. Uncertainty remains about who attends, and the health-related impacts. AIM: To review quantitative evidence on coverage (the...
Humans Cardiovascular Diseases Diabetes mellitus Program Evaluation Health Promotion Preventive Health Services National Health Programs State Medicine Delivery of Health Care Patient Acceptance of Health Care Evaluation Studies as Topic Quality Improvement Observational Studies as Topic United Kingdom
Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes
Josefin E Löfvenborg, Sofia Carlsson, Tomas Andersson, Christiane S Hampe, Albert Koulman, María Dolores Chirlaque Lopez, Paula Jakszyn, Verena A Katzke, Tilman Kühn, Cecilie Kyrø, Giovanna Masala, Peter M Nilsson, Kim Overvad, Salvatore Panico, Maria-Jose Sánchez, Yvonne van der Schouw, Matthias B Schulze, Anne Tjønneland, Elisabete Weiderpass, Elio Riboli, Nita G Forouhi, Stephen J Sharp, Olov Rolandsson, Nicholas J Wareham
Jan 15, 2021
Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes
E-M Dalsgaard, A Sandbaek, SJ Griffin, GEHM Rutten, K Khunti, MJ Davies, GJ Irving, RC Vos, DR Webb, NJ Wareham, DR Witte
Jul 29, 2020
AIMS: To present the longer-term impact of multifactorial treatment of type 2 diabetes on self-reported health status, diabetes-specific quality of life, and diabetes treatment satisfaction at 10-year follow up of the...
A Highly Tailored Text and Voice Messaging Intervention to Improve Medication Adherence in Patients With Either or Both Hypertension and Type 2 Diabetes in a UK Primary Care Setting
Aikaterini Kassavou, Venus Mirzaei, James Brimicombe, Simon Edwards, Efthalia Massou, A Toby Prevost, Simon Griffin, Stephen Sutton
Aug 03, 2020
BACKGROUND: The efficacy of a highly tailored digital intervention to support medication adherence and feasibility to support clinical effectiveness as an adjunct to the primary care setting has not been evaluated. OBJECTIVE...
Hypertension interactive voice response Medication Adherence Text Messaging Type 2 diabetes Adolescent Adult Aged Aged 80 and over Diabetes mellitus Type 2 Feasibility Studies Female Humans Hypertension Male Medication Adherence Middle Aged Quality of life Text Messaging Treatment Outcome United Kingdom Young Adult
Evidence-based prevention of Alzheimer's disease
Jin-Tai Yu, Wei Xu, Chen-Chen Tan, Sandrine Andrieu, John Suckling, Evangelos Evangelou, An Pan, Can Zhang, Jianping Jia, Lei Feng, Ee-Heok Kua, Yan-Jiang Wang, Hui-Fu Wang, Meng-Shan Tan, Jie-Qiong Li, Xiao-He Hou, Yu Wan, Lin Tan, Vincent Mok, Lan Tan, Qiang Dong, Jacques Touchon, Serge Gauthier, Paul S Aisen, Bruno Vellas
Aug 06, 2020
BACKGROUND: Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current...
Alzheimer's Disease EPIDEMIOLOGY Meta-Analysis systematic reviews Alzheimer Disease Antihypertensive Agents Cognition Craniocerebral Trauma Depression Diabetes mellitus Education Evidence-Based Medicine Exercise Humans Hyperhomocysteinemia Hypertension Hypotension Orthostatic Life Style obesity Observational Studies as Topic Randomized Controlled Trials as Topic Risk Reduction Behavior Stress Psychological
Genetic Variation in Sodium-glucose Cotransporter 2 and Heart Failure.
Julius L Katzmann, Amy M Mason, Winfried März, Marcus E Kleber, Alexander Niessner, Matthias Blüher, Thimoteus Speer, Ulrich Laufs
Dec 11, 2020
Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice.
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to...
adeno-associated virus serotype 8 (AAV8) albumin enhancer (3′iALB) diabetes gene therapy glucose responsive element (GlRE) liver-specific glucose-responsive promoter long-term basal insulin expression Animals Dependovirus Diabetes mellitus Experimental Disease Models Animal Gene Expression Genetic Therapy Genetic Vectors Glucose Hepatocytes Humans Insulin Mice Promoter Regions Genetic Transgenes
Parents' experiences of caring for a young child with type 1 diabetes
AIMS: To synthesise the qualitative evidence on parents' experiences of caring for a child aged ≤8 years with type 1 diabetes to identify: the challenges they encounter; their views about support received; ways in which support...
Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care
Simon J Griffin, Guy EHM Rutten, Kamlesh Khunti, Daniel R Witte, Torsten Lauritzen, Stephen J Sharp, Else-Marie Dalsgaard, Melanie J Davies, Greg J Irving, Rimke C Vos, David R Webb, Nicholas J Wareham, Annelli Sandbæk
Jan 15, 2020
Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study.
Dorit Samocha-Bonet, Donald J Chisholm, Fiona M Gribble, Adelle CF Coster, Kevin H Carpenter, Graham RD Jones, Jens J Holst, Jerry R Greenfield
Feb 04, 2020
BACKGROUND AND AIMS: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2...
Day and night closed-loop control in adults with type 1 diabetes
Yoeri M Luijf, J Hans DeVries, Koos Zwinderman, Lalantha Leelarathna, Marianna Nodale, Karen Caldwell, Kavita Kumareswaran, Daniela Elleri, Janet M Allen, Malgorzata E Wilinska, Mark L Evans, Roman Hovorka, Werner Doll, Martin Ellmerer, Julia K Mader, Eric Renard, Jerome Place, Anne Farret, Claudio Cobelli, Simone Del Favero, Chiara Dalla Man, Angelo Avogaro, Daniela Bruttomesso, Alessio Filippi, Rachele Scotton, Lalo Magni, Giordano Lanzola, Federico Di Palma, Paola Soru, Chiara Toffanin, Giuseppe De Nicolao, Sabine Arnolds, Carsten Benesch, Lutz Heinemann, AP@home Consortium
Feb 14, 2020
OBJECTIVE: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS: This study was a multicenter, randomized, three-way crossover...
Closed-loop basal insulin delivery over 36 hours in adolescents with type 1 diabetes
Daniela Elleri, Janet M Allen, Kavita Kumareswaran, Lalantha Leelarathna, Marianna Nodale, Karen Caldwell, Peiyao Cheng, Craig Kollman, Ahmad Haidar, Helen R Murphy, Malgorzata E Wilinska, Carlo L Acerini, David B Dunger, Roman Hovorka
Feb 21, 2020
OBJECTIVE: We evaluated the safety and efficacy of closed-loop basal insulin delivery during sleep and after regular meals and unannounced periods of exercise. RESEARCH DESIGN AND METHODS: Twelve adolescents with type 1 diabetes...
Impact of health warning labels on snack selection
Natasha Clarke, Emily Pechey, Eleni Mantzari, Anna KM Blackwell, Katie De-loyde, Richard W Morris, Marcus R Munafò, Theresa M Marteau, Gareth J Hollands
Jun 18, 2020
Excessive consumption of energy-dense food increases the risk of obesity, which in turn increases the risk of non-communicable diseases, including heart disease, type 2 diabetes and most non-smoking-related cancers. Health...
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon LR Kardia, Charles Kooperberg, Ruth JF Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, DC Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy
Jun 01, 2020
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide...
Role of AYUSH Therapies in Modern Medicine
Ashutosh Ojha, Utkarsh Ojha, Harsh Ojha, Abhinaya Chandrashekar, Raihan Mohammed, Rudra Trivedi, Sharvari Ugaonkar, Manan Desai, Ramesh Sreevidya, Pratiksha Sahu
Mar 10, 2020
OBJECTIVE: To understand doctors' attitude to and awareness of AYUSH therapies for the treatment of diabetes mellitus (DM). METHODS: This qualitative study, using a usage-and-attitude survey, was conducted in secondary centers...
Genetic aetiology of glycaemic traits
Glycaemic traits such as fasting and post-challenge glucose and insulin measures, as well as glycated haemoglobin (HbA1c), are used to diagnose and monitor diabetes. These traits are risk factors for cardiovascular disease even...
Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.
Short-term hyperglycemia suppresses superior cervical ganglia neurotransmission. If this ganglionic dysfunction also occurs in the islet sympathetic pathway, sympathetically mediated glucagon responses could be impaired. Our...
WLDS celiac ganglia fos Glucagon nicotinic acetylcholine receptors Norepinephrine sympathetic nervous system Animals Diabetes mellitus Type 1 Down-Regulation Electric Stimulation Ganglia Sympathetic Ganglionic Stimulants Glucagon Hyperglycemia Islets of Langerhans Male Mutant Proteins Nerve Tissue Proteins Neurons Nicotinic Agonists Norepinephrine Proto-Oncogene Proteins c-fos Rats Sprague-Dawley Rats Transgenic Rats Wistar Receptors Nicotinic Synaptic Transmission Wallerian degeneration
Quality of dietary fat and genetic risk of type 2 diabetes
Jordi Merino, Marta Guasch-Ferré, Christina Ellervik, Hassan S Dashti, Stephen J Sharp, Peitao Wu, Kim Overvad, Chloé Sarnowski, Mikko Kuokkanen, Rozenn N Lemaitre, Anne E Justice, Ulrika Ericson, Kim VE Braun, Yuvaraj Mahendran, Alexis C Frazier-Wood, Dianjianyi Sun, Audrey Y Chu, Toshiko Tanaka, Jian'an Luan, Jaeyoung Hong, Anne Tjønneland, Ming Ding, Annamari Lundqvist, Kenneth Mukamal, Rebecca Rohde, Christina-Alexandra Schulz, Oscar H Franco, Niels Grarup, Yii-Der Ida Chen, Lydia Bazzano, Paul W Franks, Julie E Buring, Claudia Langenberg, Ching-Ti Liu, Torben Hansen, Majken K Jensen, Katri Sääksjärvi, Bruce M Psaty, Kristin L Young, George Hindy, Camilla Helene Sandholt, Paul M Ridker, Jose M Ordovas, James B Meigs, Oluf Pedersen, Peter Kraft, Markus Perola, Kari E North, Marju Orho-Melander, Trudy Voortman, Ulla Toft, Jerome I Rotter, Lu Qi, Nita G Forouhi, Dariush Mozaffarian, Thorkild IA Sørensen, Meir J Stampfer, Satu Männistö, Elizabeth Selvin, Fumiaki Imamura, Veikko Salomaa, Frank B Hu, Nick J Wareham, Josée Dupuis, Caren E Smith, Tuomas O Kilpeläinen, Daniel I Chasman, Jose C Florez
Aug 07, 2019
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Sjur Reppe, Yunpeng Wang, Wesley K Thompson, Linda K McEvoy, Andrew J Schork, Verena Zuber, Marissa LeBlanc, Francesco Bettella, Ian G Mills, Rahul S Desikan, Srdjan Djurovic, Kaare M Gautvik, Anders M Dale, Ole A Andreassen, GEFOS Consortium
Mar 11, 2019
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but...
Closed-loop insulin delivery in suboptimally controlled type 1 diabetes
Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Yue Ruan, Judy Sibayan, Craig Kollman, Peiyao Cheng, Roy W Beck, Carlo L Acerini, Mark L Evans, David B Dunger, Daniela Elleri, Fiona Campbell, Richard M Bergenstal, Amy Criego, Viral N Shah, Lalantha Leelarathna, Roman Hovorka, APCam11 Consortium
Sep 08, 2018
BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump...
Cost-effectiveness of facilitated access to a self-management website (HeLP-Diabetes) compared to usual care for patients with Type 2 Diabetes
MJ Sweeting, Jinshuo Li, Steve Parrott, Andrew Farmer, Jamie Ross, Charlotte Dack, Kingshuk Pal, Lucy Yardley, Maria Barnard, Mohammed Hudda, Ghadah Alkhaldi, Elizabeth Murray
Sep 18, 2018
Background:
Type 2 Diabetes Mellitus is one of the commonest long term conditions, and costs health services approximately 10% of their total budget. Active self-management by patients improves outcomes and reduces health...
Risk accuracy of type 2 diabetes in middle aged adults
OBJECTIVE: To identify the proportion of individuals with an accurate perception of their risk of type 2 diabetes (T2D) prior to, immediately after and eight weeks after receiving a personalised risk estimate. Additionally, we...
Rapid model exploration for complex hierarchical data
We consider situations, which are common in medical statistics, where we have a number of sets of response data, from different individuals, say, potentially under different conditions. A parametric model is defined for each set...
Bayesian hierarchical models Markov Chain Monte Carlo Insulin Pharmacokinetics VARIABLE SELECTION Computer Simulation Data Interpretation Statistical Diabetes mellitus Type 1 Female Humans Insulin Aspart Models Biological Monte Carlo Method Pregnancy Pregnancy Complications Reproducibility of Results
Differences in objectively measured physical activity and sedentary behaviour between white Europeans and south Asians recruited from primary care
Gregory JH Biddle, Charlotte L Edwardson, Alex V Rowlands, Melanie J Davies, Danielle H Bodicoat, Wendy Hardeman, Helen Eborall, Stephen Sutton, Simon Griffin, Kamlesh Khunti, Thomas Yates
Feb 07, 2019
Participants' Experiences of, and Views About, Daytime Use of a Day-and-Night Hybrid Closed-Loop System in Real Life Settings
Julia Lawton, Maxine Blackburn, David Rankin, Janet M Allen, Fiona M Campbell, Lalantha Leelarathna, Martin Tauschmann, Hood Thabit, Malgorzata E Wilinska, Daniela Elleri, Roman Hovorka
Feb 07, 2019
OBJECTIVE: To explore individuals' experiences of daytime use of a day-and-night hybrid closed-loop system, their information and support needs, and their views about how future systems could be improved. RESEARCH DESIGN AND...
Artificial Pancreas Closed-loop system Medical device qualitative research type 1 diabetes User Experience Adolescent Adult Blood Glucose Blood Glucose Self-Monitoring Diabetes mellitus Type 1 Female Humans Hypoglycemic Agents Insulin Insulin Infusion Systems Longitudinal Studies Male Middle Aged Parents Patient Acceptance of Health Care qualitative research Time Factors Young Adult
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