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Evaluating the sustained health impact of household chlorination of drinking water in rural Haiti.
The Jolivert Safe Water for Families program has sold sodium hypochlorite solution (chlorine) and conducted household visits in rural Haiti since 2002. To assess the impact of the program on diarrheal disease, in 2010 we...
Phase 1 dose-escalation study of S-222611, an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, in patients with solid tumours.
J Spicer, R Baird, A Suder, N Cresti, J Garcia Corbacho, L Hogarth, E Frenkel, S Matsumoto, I Kawabata, K Donaldson, J Posner, D Sarker, D Jodrell, R Plummer
Mar 20, 2015
EGFR HER2 HER4 Phase 1 clinical trial Protein kinase inhibitor Administration Oral Adult Aged Area Under Curve Diarrhea Dose-Response Relationship Drug Drug Administration Schedule ErbB Receptors Exanthema fatigue Female Humans Male Metabolic Clearance Rate Middle Aged Neoplasms Protein Kinase Inhibitors Quinazolines Receptor ErbB-2 Treatment Outcome Young Adult
Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA.
Genevieve L Wojcik, Poonum Korpe, Chelsea Marie, Alexander J Mentzer, Tommy Carstensen, Josyf Mychaleckyj, Beth D Kirkpatrick, Stephen S Rich, Patrick Concannon, ASG Faruque, Rashidul Haque, William A Petri, Priya Duggal
Mar 10, 2020
Diarrhea is a major cause of both morbidity and mortality worldwide, especially among young children. Cryptosporidiosis is a leading cause of diarrhea in children, particularly in South Asia and sub-Saharan Africa, where it is...
Cryptosporidium Genetics genome analysis Bangladesh Cryptosporidiosis Cryptosporidium Diarrhea Disease Susceptibility Feces Female Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Meta-Analysis as Topic Polymorphism Single Nucleotide Prospective Studies Protein Kinase C-alpha Risk Factors