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Targeting Mitochondrial Metabolism in Neuroinflammation
The lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets....
immune metabolism MACROPHAGES Microglia Mitochondria Neuroinflammation progressive multiple sclerosis Central Nervous System Crotonates Dimethyl Fumarate Electron Transport Glymphatic System Humans Hydroxybutyrates Immunity Innate Metabolic Networks and Pathways Microglia Mitochondria Molecular Targeted Therapy Mononuclear Phagocyte System Multiple Sclerosis Chronic Progressive Neurodegenerative Diseases Nitriles Signal Transduction Stem Cell Transplantation Toluidines
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study.
David H Miller, Robert J Fox, J Theodore Phillips, Michael Hutchinson, Eva Havrdova, Mariko Kita, Claudia AM Wheeler-Kingshott, Daniel J Tozer, David G MacManus, Tarek A Yousry, Mary Goodsell, Minhua Yang, Ray Zhang, Vissia Viglietta, Katherine T Dawson, CONFIRM study investigators
Jun 22, 2018
OBJECTIVE: To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator...