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Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.
Zhifen Chen, Haojie Yu, Xu Shi, Curtis R Warren, Luca A Lotta, Max Friesen, Torsten B Meissner, Claudia Langenberg, Martin Wabitsch, Nick Wareham, Mark D Benson, Rob E Gerszten, Chad A Cowan
Nov 25, 2019
Rationale: Genome-wide association studies have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes...
Adipocytes Adipogenesis Diabetes mellitus Type 2 Insulin Resistance lipid metabolis Adaptor Proteins Signal Transducing Adipocytes Cell Line Dipeptidases Follistatin Genome-Wide Association Study Humans Insulin Receptor Substrate Proteins Insulin Resistance Loss of Function Mutation Lymphokines MAP Kinase Kinase Kinase 1 PPAR gamma Platelet-Derived Growth Factor Quantitative Trait Loci