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HCMV Antivirals and Strategies to Target the Latent Reservoir.
Gene drives for schistosomiasis transmission control.
Theresa Maier, Nicolas James Wheeler, Erica KO Namigai, Josh Tycko, Richard Ernest Grewelle, Yimtubezinash Woldeamanuel, Katharina Klohe, Javier Perez-Saez, Susanne H Sokolow, Giulio A De Leo, Timothy P Yoshino, Mostafa Zamanian, Jutta Reinhard-Rupp
Jan 27, 2020
Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas....
Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer.
Suresh V Kuchipudi, Meera Surendran-Nair, Rachel M Ruden, Michele Yon, Ruth H Nissly, Kurt J Vandegrift, Rahul K Nelli, Lingling Li, Bhushan M Jayarao, Costas D Maranas, Nicole Levine, Katriina Willgert, Andrew JK Conlan, Randall J Olsen, James J Davis, James M Musser, Peter J Hudson, Vivek Kapur
Feb 26, 2022
Many animal species are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and could act as reservoirs; however, transmission in free-living animals has not been documented. White-tailed deer...
Ebola
Jonathan L Heeney
Dec 03, 2015
Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations.
Raina K Plowright, Alison J Peel, Daniel G Streicker, Amy T Gilbert, Hamish McCallum, James Wood, Michelle L Baker, Olivier Restif
Jun 15, 2016
Dose-response and transmission
Tamika J Lunn, Olivier Restif, Alison J Peel, Vincent J Munster, Emmie de Wit, Sanna Sokolow, Neeltje van Doremalen, Peter Hudson, Hamish McCallum
May 07, 2019
A novel, sensitive dual-indicator cell line for detection and quantification of inducible, replication-competent latent HIV-1 from reservoir cells.
Fanny Salasc, David W Gludish, Isobel Jarvis, Saikat Boliar, Mark R Wills, David G Russell, Andrew ML Lever, Hoi-Ping Mok
Nov 21, 2019
What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts.
Emma E Glennon, Daniel J Becker, Alison J Peel, Romain Garnier, Richard D Suu-Ire, Louise Gibson, David TS Hayman, James LN Wood, Andrew A Cunningham, Raina K Plowright, Olivier Restif
Jun 20, 2019
Experimental Lagos bat virus infection in straw-colored fruit bats
Lineke Begeman, Richard Suu-Ire, Ashley C Banyard, Christian Drosten, Elisa Eggerbauer, Conrad M Freuling, Louise Gibson, Hooman Goharriz, Daniel L Horton, Daisy Jennings, Denise A Marston, Yaa Ntiamoa-Baidu, Silke Riesle Sbarbaro, David Selden, Emma L Wise, Thijs Kuiken, Anthony R Fooks, Thomas Müller, James LN Wood, Andrew A Cunningham
Feb 01, 2021
Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are...
Support for viral persistence in bats from age-specific serology and models of maternal immunity.
Alison J Peel, Kate S Baker, David TS Hayman, Christopher C Broder, Andrew A Cunningham, Anthony R Fooks, Romain Garnier, James LN Wood, Olivier Restif
May 17, 2018
Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain...
Pathogenesis of bat rabies in a natural reservoir
Richard Suu-Ire, Lineke Begeman, Ashley C Banyard, Andrew C Breed, Christian Drosten, Elisa Eggerbauer, Conrad M Freuling, Louise Gibson, Hooman Goharriz, Daniel L Horton, Daisy Jennings, Ivan V Kuzmin, Denise Marston, Yaa Ntiamoa-Baidu, Silke Riesle Sbarbaro, David Selden, Emma L Wise, Thijs Kuiken, Anthony R Fooks, Thomas Müller, James LN Wood, Andrew A Cunningham
Jul 17, 2018
Rabies is a fatal neurologic disease caused by lyssavirus infection. People are infected through contact with infected animals. The relative increase of human rabies acquired from bats calls for a better understanding of...
Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.
Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing latently infected cells could have far-reaching clinical benefits. In...
Antigens CD34 Cell Death Cells Cultured Chemokines Cytomegalovirus Disease Reservoirs Endocytosis Genes Viral Hematopoietic Stem Cell Transplantation Humans Lipopolysaccharide Receptors Monocytes Receptors Chemokine Recombinant Fusion Proteins Stem Cells Viral Load Viral Proteins Virus Activation Virus Latency
The future of zoonotic risk prediction.
Colin J Carlson, Maxwell J Farrell, Zoe Grange, Barbara A Han, Nardus Mollentze, Alexandra L Phelan, Angela L Rasmussen, Gregory F Albery, Bernard Bett, David M Brett-Major, Lily E Cohen, Tad Dallas, Evan A Eskew, Anna C Fagre, Kristian M Forbes, Rory Gibb, Sam Halabi, Charlotte C Hammer, Rebecca Katz, Jason Kindrachuk, Renata L Muylaert, Felicia B Nutter, Joseph Ogola, Kevin J Olival, Michelle Rourke, Sadie J Ryan, Noam Ross, Stephanie N Seifert, Tarja Sironen, Claire J Standley, Kishana Taylor, Marietjie Venter, Paul W Webala
Oct 21, 2021
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat...
Genomic Analysis of Salmonella enterica Serovar Typhimurium from Wild Passerines in England and Wales.
Alison E Mather, Becki Lawson, Elizabeth de Pinna, Paul Wigley, Julian Parkhill, Nicholas R Thomson, Andrew J Page, Mark A Holmes, Gavin K Paterson
Oct 25, 2016
Animals Animals Wild Bacteriophage Typing Bird Diseases Cats Disease Reservoirs Drug Resistance Bacterial England Genome Bacterial Genomics Humans Multilocus Sequence Typing Phylogeny Plasmids Polymorphism Single Nucleotide Salmonella Infections Salmonella Infections Animal Salmonella typhimurium Serogroup Serotyping Sparrows Virulence Wales
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
Stephanie Bertram, Adeline Heurich, Hayley Lavender, Stefanie Gierer, Simon Danisch, Paula Perin, Jared M Lucas, Peter S Nelson, Stefan Pöhlmann, Elizabeth J Soilleux
Dec 21, 2018
The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host....
Angiotensin-Converting Enzyme 2 Animals Birds Cell Line Disease Reservoirs Enzyme Activation Gastrointestinal Tract Gene Expression Humans Influenza Human Orthomyxoviridae Peptidyl-Dipeptidase A Receptors Virus Respiratory System Severe acute respiratory syndrome-related coronavirus Serine Endopeptidases Severe Acute Respiratory Syndrome Sialic Acids Swine
Longitudinal Secretion of Paramyxovirus RNA in the Urine of Straw-Coloured Fruit Bats (Eidolon helvum).
Elli Rosa Jolma, Louise Gibson, Richard D Suu-Ire, Grace Fleischer, Samuel Asumah, Sylvester Languon, Olivier Restif, James LN Wood, Andrew A Cunningham
Nov 09, 2021
The straw-coloured fruit bat (Eidolon helvum) is widespread in sub-Saharan Africa and is widely hunted for bushmeat. It is known to harbour a range of paramyxoviruses, including rubuloviruses and henipaviruses, but the zoonotic...
Nine challenges in modelling the emergence of novel pathogens.
Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats.
David TS Hayman, Angela D Luis, Olivier Restif, Kate S Baker, Anthony R Fooks, Clint Leach, Daniel L Horton, Richard Suu-Ire, Andrew A Cunningham, James LN Wood, Colleen T Webb
Oct 10, 2018
Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial.
Andries J van Tonder, Mark J Thornton, Andrew JK Conlan, Keith A Jolley, Lee Goolding, Andrew P Mitchell, James Dale, Eleftheria Palkopoulou, Philip J Hogarth, R Glyn Hewinson, James LN Wood, Julian Parkhill
Jan 07, 2022
Mycobacterium bovis (M. bovis) is a causative agent of bovine tuberculosis, a significant source of morbidity and mortality in the global cattle industry. The Randomised Badger Culling Trial was a field experiment carried out...