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Results: 6
Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task.
RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the...
Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators.
Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia...
NMDA receptors Glutamate Impulsivity mGluR5 Prefrontal Cortex Allosteric Regulation Animals Dizocilpine Maleate Excitatory Amino Acid Antagonists Glutamic Acid Imidazoles Male Oxadiazoles Piperidines Prefrontal Cortex Pyridines Rats Rats Wistar Receptor Metabotropic Glutamate 5 Receptors N-Methyl-D-Aspartate
Saccharin fading is not required for the acquisition of alcohol self-administration, and can alter the dynamics of cue-alcohol memory reconsolidation.
RATIONALE: Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive...
Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats
Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke.
Maria Ashioti, John S Beech, Andrew S Lowe, Michel Bernanos, Andrew McCreary, Michel M Modo, Steve CR Williams
Jun 13, 2011
Animals Cerebral Cortex Cytoprotection Dizocilpine Maleate Infarction Middle Cerebral artery Magnetic Resonance Imaging Male Neurons Neuropsychological Tests Outcome Assessment Health Care Rats Rats Inbred SHR Rats Sprague-Dawley Serotonin 5-HT1 Receptor Agonists Serotonin Receptor Agonists Time Factors
NMDA glutamate receptor glutamate transporter metabotropic glutamate receptor substantia nigra pars compacta Amino Acids Animals Aspartic Acid Dizocilpine Maleate Dopaminergic Neurons Electric Stimulation Excitatory Amino Acid Antagonists Excitatory Postsynaptic Potentials Glutamic Acid Male Mice Mice Inbred C57BL Receptors N-Methyl-D-Aspartate Substantia Nigra Synapses Xanthenes