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Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat.
Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams.
Justin K Ellis, Shawn F Sorrells, Sasha Mikhailova, Manideep Chavali, Sandra Chang, Khalida Sabeur, Patrick Mcquillen, David H Rowitch
May 13, 2019
The human early postnatal brain contains late migratory streams of immature interneurons that are directed to cortex and other focal brain regions. However, such migration is not observed in rodent brain, and whether other small...
RRID: AB839504 RRID: AB_1640532 RRID:AB_10000320 RRID:AB_10615497 RRID:AB_1079874 RRID:AB_1586992 RRID:AB_2069869 RRID:AB_2194626 RRID:AB_2195374 RRID:AB_2298772 RRID:AB_305869 RRID:AB_477010 RRID:AB_561007 RRID:AB_882455 cortical interneurons dorsal migratory stream doublecortin ferret medial migratory stream posterior migratory stream postnatal migration Prefrontal Cortex secretagogin Animals Brain Caspase 3 Cell Movement Doublecortin Domain Proteins Doublecortin Protein Ferrets Humans Interneurons Microtubule-Associated Proteins Neuropeptides Secretagogins white matter
Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus.