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Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D Milsom, Medhanie A Mulaw, Hartmut Geiger, Maria Carolina Florian
Nov 15, 2019
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing...
aging Animals Bone Marrow Capillaries Cell Differentiation Cell Division Cell Polarity Cell Tracking Doxycycline Fluorouracil Gene Expression Regulation Genes Reporter Green Fluorescent Proteins Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Histones Homeostasis Jagged-2 Protein Mice Mice Inbred C57BL Mice Transgenic Myeloablative Agonists Stem Cell Niche
Randomized Trial of Ciprofloxacin Doxycycline and Hydroxychloroquine Versus Budesonide in Active Crohn's Disease.
Jonathan M Rhodes, Sreedhar Subramanian, Paul K Flanagan, Graham W Horgan, Kate Martin, John Mansfield, Miles Parkes, Ailsa Hart, Helen Dallal, Tariq Iqbal, Jeffrey Butterworth, Kate Culshaw, Christopher Probert
Jan 26, 2021
BACKGROUND: Increased mucosa-associated E. coli are present in Crohn's disease, but their role in pathogenesis is uncertain. AIMS: To assess efficacy and safety of an antibiotic/hydroxychloroquine combination effective against...
Single-copy Snail upregulation causes partial epithelial-mesenchymal transition in colon cancer cells.
Carprofen-induced depletion of proton motive force reverses TetK-mediated doxycycline resistance in methicillin-resistant Staphylococcus pseudintermedius.
Zofia Magnowska, Bimal Jana, Rikke Prejh Brochmann, Andrew Hesketh, Rene Lametsch, Cristian De Gobba, Luca Guardabassi
Nov 27, 2020
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.
Richard Mair, Alan J Wright, Susana Ros, De-En Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts, Kevin M Brindle
Oct 03, 2018