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Results: 41
A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration.
DI Jodrell, A Bowman, R Rye, B Byrne, A Boddy, I Rafi, GA Taylor, A Johnston, NJ Clendeninn
Sep 02, 2020
2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug...
Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study.
Dorit Samocha-Bonet, Donald J Chisholm, Fiona M Gribble, Adelle CF Coster, Kevin H Carpenter, Graham RD Jones, Jens J Holst, Jerry R Greenfield
Feb 04, 2020
BACKGROUND AND AIMS: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2...
Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison, United Kingdom Medical Research Council Primary Thrombocythemia-1 Study, United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup, French Intergroup of Myeloproliferative Neoplasms, the Australasian Leukaemia and Lymphoma Group.
Sep 29, 2018
Adult Aspirin Australia Disease Progression Dose-Response Relationship Drug Drug Administration Schedule Drug Therapy Combination Female France Humans Hydroxyurea Internationality Ireland Janus Kinase 2 Kaplan-Meier Estimate Male Middle Aged New Zealand Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Severity of Illness Index Thrombocythemia Essential Thrombosis Treatment Outcome United Kingdom
Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma
Ellie Edlmann, Eric P Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G Kolias, Peter JA Hutchinson, Dex-CSDH trial collaborative and BNTRC collaborative.
Mar 08, 2019
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST)
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker, United Kingdom Clinical Infection Research Group (UKCIRG)
Jun 27, 2018
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed...
An alternative sensor-based method for glucose monitoring in children and young people with diabetes.
Julie Edge, Carlo Acerini, Fiona Campbell, Julian Hamilton-Shield, Chris Moudiotis, Shakeel Rahman, Tabitha Randell, Anne Smith, Nicola Trevelyan
Aug 17, 2017
OBJECTIVE: To determine accuracy, safety and acceptability of the FreeStyle Libre Flash Glucose Monitoring System in the paediatric population. DESIGN, SETTING AND PATIENTS: Eighty-nine study participants, aged 4-17 years, with...
RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA)
Duncan Edwards, Kate Fletcher, Rachel Deller, Richard McManus, Daniel Lasserson, Matthew Giles, Don Sims, John Norrie, Graham McGuire, Simon Cohn, Fiona Whittle, Vikki Hobbs, Christopher Weir, Jonathan Mant
Jul 17, 2013
Antihypertensive Agents Aspirin Cardiovascular Agents Clinical Protocols Dipyridamole Drug Administration Schedule Drug Therapy Combination Emergency Service hospital England Feasibility Studies General Practice Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Ischemic Attack Transient Pilot Projects Primary Health Care Referral and Consultation Research Design Secondary Prevention Simvastatin Time Factors Treatment Outcome
Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
Navin Goyal, Pete Skrdla, Rosemary Schroyer, Subramanya Kumar, Disala Fernando, Anna Oughton, Nicola Norton, Dennis L Sprecher, Joseph Cheriyan
Feb 18, 2019
Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
Pharmacokinetics of diluted (U20) insulin aspart compared with standard (U100) in children aged 3-6 years with type 1 diabetes during closed-loop insulin delivery
Yue Ruan, Daniela Elleri, Janet M Allen, Martin Tauschmann, Malgorzata E Wilinska, David B Dunger, Roman Hovorka
Feb 17, 2015
A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours.
BB-3644 is an oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI) structurally related to marimastat and BB-94. It is also >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha....
Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease.
EEG power Gamma oscillation Cognitive enhancer Delta rapid eye movement sleep theta Animals Disease Models Animal Dose-Response Relationship Drug Drug Administration Schedule Electroencephalography Huntington Disease Male Mice Mice Inbred C57BL Mice Transgenic Modafinil Sleep Stages Wakefulness Wakefulness-Promoting Agents
Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma.
Secondary adrenal insufficiency (AI) occurs as the result of any process that disrupts normal hypothalamic and/or anterior pituitary function and causes a decrease in the secretion of steroid hormones from the adrenal cortex....
A randomised controlled trial of early insulin therapy in very low birth weight infants, "NIRTURE" (neonatal insulin replacement therapy in Europe).
Kathryn Beardsall, Sophie Vanhaesebrouck, Amanda L Ogilvy-Stuart, Jag S Ahluwalia, Christine Vanhole, Christopher Palmer, Paula Midgley, Mike Thompson, Luc Cornette, Mirjam Weissenbruch, Marta Thio, Francis de Zegher, David Dunger
Jun 14, 2011
BACKGROUND: Studies in adult intensive care have highlighted the importance of insulin and improved glucose control on survival, with 32% reduction in mortality, 22% reduction in intensive care stay and halving of the incidence...
Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults
Carlos A Camargo, Les Toop, John Sluyter, Carlene MM Lawes, Debbie Waayer, Kay-Tee Khaw, Adrian R Martineau, Robert Scragg
Feb 07, 2021
Randomized controlled trials have suggested that vitamin D supplementation can prevent asthma and chronic obstructive pulmonary disease (COPD) exacerbations. For COPD, the benefit appears to be limited to individuals with...
Asthma Chronic obstructive pulmonary disease exacerbations oral corticosteroids Randomized controlled trial supplement vitamin D Aged Asthma Dietary Supplements Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Proportional Hazards Models Pulmonary Disease Chronic Obstructive Secondary Prevention Symptom Flare Up Treatment Outcome vitamin D Vitamin D Deficiency Vitamins
Safety, efficacy and glucose turnover of reduced prandial boluses during closed-loop therapy in adolescents with type 1 diabetes
D Elleri, M Biagioni, JM Allen, K Kumareswaran, L Leelarathna, K Caldwell, M Nodale, ME Wilinska, A Haidar, P Calhoun, C Kollman, NC Jackson, AM Umpleby, CL Acerini, DB Dunger, R Hovorka
Aug 11, 2015
closed-loop insulin delivery postprandial hypoglycaemia type 1 diabetes Adolescent Algorithms Blood Glucose Cross-Over Studies Diabetes mellitus Type 1 Drug Administration Schedule England Female Glycemic Load Humans Hyperinsulinism Hypoglycemia Hypoglycemic Agents Injections Subcutaneous Insulin Insulin Infusion Systems Insulin Resistance Male Meals Monitoring Physiologic risk
Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma.
PG Corrie, W Qian, B Basu, JW Valle, S Falk, C Lwuji, H Wasan, D Palmer, M Scott-Brown, J Wadsley, S Arif, J Bridgewater, D Propper, R Gillmore, A Gopinathan, R Skells, P Bundi, R Brais, K Dalchau, L Bax, A Chhabra, A Machin, A Dayim, K McAdam, S Cummins, L Wall, R Ellis, A Anthoney, J Evans, YT Ma, C Isherwood, A Neesse, D Tuveson, DI Jodrell
May 11, 2020
BACKGROUND: Nab-paclitaxel plus gemcitabine (nabP+gemcitabine) offers modest survival gains for patients with metastatic pancreatic ductal adenocarcinoma (PDAC). Sequential scheduling of nabP+gemcitabine in a PDAC mouse model...
Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers.
Marianne Hauglid Flågeng, Alexey Larionov, Jürgen Geisler, Stian Knappskog, Wenche S Prestvik, Geir Bjørkøy, Peer Kåre Lilleng, J Michael Dixon, William R Miller, Per Eystein Lønning, Gunnar Mellgren
Aug 01, 2016
Breast Cancer Endocrine therapy ErbB Neuregulin-1 Anastrozole Aromatase Inhibitors Breast Neoplasms DNA Mutational Analysis Drug Administration Schedule ErbB Receptors Estrogen Receptor alpha Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Immunohistochemistry Letrozole Mutation Neuregulin-1 Nitriles RNA Messenger Receptor ErbB-2 Treatment Outcome Triazoles
Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects.
Debra J Tompson, Carwyn Davies, Nicola E Scott, Edward P Cannons, Michalis Kostapanos, Annette S Gross, Marcy Powell, Hiroko Ino, Ryutaro Shimamura, Hirofumi Ogura, Takashi Nagakubo, Harue Igarashi, Atsushi Nakano
Jan 18, 2021
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study)
Mariam Al-Laith, Marianna Jasenecova, Sonya Abraham, Aisla Bosworth, Ian N Bruce, Christopher D Buckley, Coziana Ciurtin, Maria-Antonietta D'Agostino, Paul Emery, Hill Gaston, John D Isaacs, Andrew Filer, Benjamin A Fisher, Thomas WJ Huizinga, Pauline Ho, Clare Jacklin, Heidi Lempp, Iain B McInnes, Arthur G Pratt, Andrew Östor, Karim Raza, Peter C Taylor, Dirkjan van Schaardenburg, Dharshene Shivapatham, Alison J Wright, Joana C Vasconcelos, Joanna Kelly, Caroline Murphy, A Toby Prevost, Andrew P Cope
Jul 14, 2020
TRIAL DESIGN: We present a study protocol for a multi-centre, randomised, double-blind, parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of a 52-week period of...
Abatacept Antibodies to citrullinated protein antigens At risk Autoantibodies Double-blind intervention Placebo-controlled Pre-clinical phase Randomised rheumatoid arthritis Abatacept Antirheumatic Agents Arthritis Rheumatoid Autoantibodies Biomarkers Double-Blind Method Drug Administration Schedule Feasibility Studies Female Humans Male Multicenter Studies as Topic Netherlands Pregnancy Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps
Carl Philpott, Steffi Le Conte, David Beard, Jonathan Cook, William Sones, Steve Morris, Caroline S Clarke, Mike Thomas, Paul Little, Jane Vennik, Valerie Lund, Helen Blackshaw, Anne Schilder, Stephen Durham, Spiros Denaxas, James Carpenter, James Boardman, Claire Hopkins, MACRO programme team
Feb 24, 2020
BACKGROUND: Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults reported CRS symptoms in a worldwide population study. Guidelines are conflicting regarding whether antibiotics should be included in...
Chronic rhinosinusitis clarithromycin endoscopic sinus surgery randomised controlled trial Administration Oral Anti-Bacterial Agents Chronic Disease Clarithromycin Comparative Effectiveness Research Drug Administration Schedule endoscopy Female Humans Male Multicenter Studies as Topic Nasal Polyps Nasal Surgical Procedures Pilot Projects Randomized Controlled Trials as Topic Rhinitis Sinusitis Time Factors Treatment Outcome United Kingdom
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE)
Helena M Earl, Louise Hiller, Anne-Laure Vallier, Shrushma Loi, Karen McAdam, Luke Hughes-Davies, Adrian N Harnett, Mei-Lin Ah-See, Richard Simcock, Daniel Rea, Sanjay Raj, Pamela Woodings, Mark Harries, Donna Howe, Kerry Raynes, Helen B Higgins, Maggie Wilcox, Chris Plummer, Janine Mansi, Ioannis Gounaris, Betania Mahler-Araujo, Elena Provenzano, Anita Chhabra, Jean E Abraham, Carlos Caldas, Peter S Hall, Christopher McCabe, Claire Hulme, David Miles, Andrew M Wardley, David A Cameron, Janet A Dunn, PERSEPHONE Steering Committee and Trial Investigators
Mar 08, 2019
Adult Aged Aged 80 and over Antineoplastic Agents Immunological Breast Neoplasms Chemotherapy Adjuvant Disease-Free Survival Drug Administration Schedule Female Humans Infusions Intravenous Injections Subcutaneous Middle Aged Prospective Studies Receptor ErbB-2 Trastuzumab Treatment Outcome United Kingdom Young Adult
The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L Arbon, Katerina Anselmiova, Neil M Walker, Ravinder Atkar, Marcin L Pekalski, Ed Rytina, Mark Evans, Linda S Wicker, John A Todd, Adrian P Mander, Simon Bond, Frank Waldron-Lynch
Nov 21, 2018
Autoimmune Diseases Autoimmunity Clinical Trials Diabetes T cells Adolescent Adult Aged Diabetes mellitus Type 1 Dose-Response Relationship Drug Drug Administration Schedule Feasibility Studies Female Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Activation Lymphocyte Count Male Middle Aged Recombinant Proteins T-Lymphocytes Regulatory Treatment Outcome Young Adult
Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma. A Delphi Study.
Carey M Suehs, Andrew Menzies-Gow, David Price, Eugene R Bleecker, Giorgio Walter Canonica, Mark Gurnell, Arnaud Bourdin, Oral Corticosteroids Tapering Delphi Expert Panel
Oct 26, 2020
Rationale: There is a need to minimize oral corticosteroid (OCS) use in patients with asthma to prevent their costly and burdensome adverse effects. Current guidelines do not provide recommendations for OCS tapering in patients...
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