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BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates
Norikazu Kiguchi, H Ding, Gerta Cami-Kobeci, D. D. Sukhtankar, P. W. Czoty, H. B. DeLoid, F. -C. Hsu, L. Toll, Stephen Husbands, M. C. Ko
Jun 01, 2019
Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and...
The human proton pump inhibitors inhibit <i>Mycobacterium tuberculosis</i> rifampicin efflux and macrophage-induced rifampicin tolerance.
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
Mar 13, 2023
Tuberculosis treatment requires months-long combination chemotherapy with multiple drugs, with shorter treatments leading to relapses. A major impediment to shortening treatment is that Mycobacterium tuberculosis becomes...
BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates
Norikazu Kiguchi, H Ding, Gerta Cami-Kobeci, D. D. Sukhtankar, P. W. Czoty, H. B. DeLoid, F. -C. Hsu, L. Toll, Stephen Husbands, M. C. Ko
Jun 01, 2019
Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and...
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Jason SL Yu, Clara Correia-Melo, Francisco Zorrilla, Lucia Herrera-Dominguez, Mary Y Wu, Johannes Hartl, Kate Campbell, Sonja Blasche, Marco Kreidl, Anna-Sophia Egger, Christoph B Messner, Vadim Demichev, Anja Freiwald, Michael Mülleder, Michael Howell, Judith Berman, Kiran R Patil, Mohammad Tauqeer Alam, Markus Ralser
Apr 22, 2022
Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs for amino acid biosynthesis pathways in...
Addressing opioid tolerance and opioid-induced hypersensitivity
Opioids are a commonly prescribed and efficacious medication for the treatment of chronic pain but major side effects such as addiction, respiratory depression, analgesic tolerance, and paradoxical pain hypersensitivity make...