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Policy and Science for Global Health Security
Kavita M Berger, James LN Wood, Bonnie Jenkins, Jennifer Olsen, Stephen S Morse, Louise Gresham, J Jeffrey Root, Margaret Rush, David Pigott, Taylor Winkleman, Melinda Moore, Thomas R Gillespie, Jennifer B Nuzzo, Barbara A Han, Patricia Olinger, William B Karesh, James N Mills, Joseph F Annelli, Jamie Barnabei, Daniel Lucey, David TS Hayman
Apr 17, 2019
The global burden of infectious diseases and the increased attention to natural, accidental, and deliberate biological threats has resulted in significant investment in infectious disease research. Translating the results of...
Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days.
Boubacar Diallo, Daouda Sissoko, Nicholas J Loman, Hadja Aïssatou Bah, Hawa Bah, Mary Claire Worrell, Lya Saidou Conde, Ramata Sacko, Samuel Mesfin, Angelo Loua, Jacques Katomba Kalonda, Ngozi A Erondu, Benjamin A Dahl, Susann Handrick, Ian Goodfellow, Luke W Meredith, Matthew Cotten, Umaru Jah, Raoul Emeric Guetiya Wadoum, Pierre Rollin, N'Faly Magassouba, Denis Malvy, Xavier Anglaret, Miles W Carroll, Raymond Bruce Aylward, Mamoudou Harouna Djingarey, Abdoulaye Diarra, Pierre Formenty, Sakoba Keïta, Stephan Günther, Andrew Rambaut, Sophie Duraffour
Jun 12, 2018
We report on an Ebola virus disease (EVD) survivor who showed Ebola virus in seminal fluid 531 days after onset of disease. The persisting virus was sexually transmitted in February 2016, about 470 days after onset of symptoms...
Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases.
Armando Arias, Simon J Watson, Danny Asogun, Ekaete Alice Tobin, Jia Lu, My VT Phan, Umaru Jah, Raoul Emeric Guetiya Wadoum, Luke Meredith, Lucy Thorne, Sarah Caddy, Alimamy Tarawalie, Pinky Langat, Gytis Dudas, Nuno R Faria, Simon Dellicour, Abdul Kamara, Brima Kargbo, Brima Osaio Kamara, Sahr Gevao, Daniel Cooper, Matthew Newport, Peter Horby, Jake Dunning, Foday Sahr, Tim Brooks, Andrew JH Simpson, Elisabetta Groppelli, Guoying Liu, Nisha Mulakken, Kate Rhodes, James Akpablie, Zabulon Yoti, Margaret Lamunu, Esther Vitto, Patrick Otim, Collins Owilli, Isaac Boateng, Lawrence Okoror, Emmanuel Omomoh, Jennifer Oyakhilome, Racheal Omiunu, Ighodalo Yemisis, Donatus Adomeh, Solomon Ehikhiametalor, Patience Akhilomen, Chris Aire, Andreas Kurth, Nicola Cook, Jan Baumann, Martin Gabriel, Roman Wölfel, Antonino Di Caro, Miles W Carroll, Stephan Günther, John Redd, Dhamari Naidoo, Oliver G Pybus, Andrew Rambaut, Paul Kellam, Ian Goodfellow, Matthew Cotten
Jun 13, 2018
To end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing of cases and contacts was required. The ability to quickly identify unknown sources...
Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.
Christopher J Penny, Kristin Vassileva, Archana Jha, Yu Yuan, Xavier Chee, Elizabeth Yates, Michela Mazzon, Bethan S Kilpatrick, Shmuel Muallem, Mark Marsh, Taufiq Rahman, Sandip Patel
Jan 18, 2021
Two-pore channels (TPCs) are Ca2+-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including viruses. As a result, TPCs are emerging as important drug targets....
Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers.
William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs
Oct 27, 2020
Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles...