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Results: 4
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Yang, Wenjuan Zhang, Alexey G Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew Y Peak-Chew, Takashi Saito, Takaomi C Saido, Jennifer Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors HW Scheres
Feb 13, 2023
Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
Yang Shi, Alexey G. Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L. Newell, Ruben Vidal, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H. W. Scheres, Michel Goedert
Apr 14, 2021
Abstract: Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607...
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors HW Scheres, Michel Goedert
Nov 27, 2018
The ordered assembly of tau protein into abnormal filaments is a defining characteristic of Alzheimer's disease (AD) and other neurodegenerative disorders. It is not known if the structures of tau filaments vary within, or...
Alzheimer’s disease Electron cryo-microscopy Immuno-gold negative-stain electron microscopy Neurodegenerative Diseases Paired helical filaments Straight filaments Tau protein Aged Aged 80 and over Alzheimer Disease Amyloid beta-Protein Precursor Apolipoproteins E Brain Cryoelectron Microscopy Female Humans Male Microscopy Immunoelectron Middle Aged Models Anatomic Mutation Neurofibrillary Tangles Exome Sequencing tau Proteins
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors HW Scheres, Michel Goedert
Aug 02, 2021
Tau and Aβ assemblies of Alzheimer's disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is...
Alzheimer’s disease Electron cryo-microscopy Immunopurification positron emission tomography Posterior cortical atrophy Primary age-related tauopathy Aged Aged 80 and over Alzheimer Disease Benzothiazoles Binding Sites Cryoelectron Microscopy Female Fluorine Radioisotopes Humans Ligands Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals tau Proteins