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Results: 65
Bilateral risk-reducing mastectomy and reconstruction–A 12-year review of methodological trends and outcomes at a tertiary referral centre
Introduction
Bilateral risk-reducing mastectomy (BRRM) involves removal of healthy breast tissue to substantially decrease the risk of developing breast cancer in...
Aiman Aslam, Zaki Arshad, Amir Ahmed, Chien Lin Soh, Fawz Kazzazi, John R Benson, Parto Forouhi, Amit Agrawal, Sarah L Benyon, Michael Irwin, Charles M Malata
Apr 12, 2023
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity
Zhengzheng S. Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E. Vancollie, Ximena Ibarra-Soria, Helen V. Firth, Debra Rimmington, I. Sadaf Farooqi, Christopher J. Lelliott, Steven C. Munger, Stephen O’Rahilly, Anne C. Ferguson-Smith, Anthony P. Coll, Darren W. Logan
Sep 02, 2020
Some imprinted genes exhibit parental origin specific expression bias rather than being transcribed exclusively from one copy. The physiological relevance of this remains poorly understood. In an analysis of brain-specific...
Intracellular neutralisation of rotavirus by VP6-specific IgG
Sarah L. Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O‘Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gómara, Ulrich Desselberger, Leo C. James
Aug 14, 2020
Identifying anthropogenic features at Seoke (Botswana) using pXRF
Stefano Biagetti, Jonas Alcaina-Mateos, Abel Ruiz-Giralt, Carla Lancelotti, Patricia Groenewald, Jordi Ibañez-Insa, Shira Gur-Arie, Fred Morton, Stefania Merlo
May 12, 2021
A novel system for classifying tooth root phenotypes.
Human root and canal number and morphology are highly variable, and internal root canal form and count does not necessarily co-vary directly with external morphology. While several typologies and classifications have been...
High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model.
Marilyn Gatica, Fernando E Rosas, Pedro A M Mediano, Ibai Diez, Stephan P Swinnen, Patricio Orio, Rodrigo Cofré, Jesus M Cortes
Sep 15, 2022
The association between number and ages of children and the physical activity of mothers
Rachel F Simpson, Kathryn R Hesketh, Sarah R Crozier, Janis Baird, Cyrus Cooper, Keith M Godfrey, Nicholas C Harvey, Kate Westgate, Hazel M Inskip, Esther Mf van Sluijs
Nov 16, 2022
Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures
Christopher Y. K. Williams, Adam T. Townson, Milan Kapur, Alice F. Ferreira, Rebecca Nunn, Julieta Galante, Veronica Phillips, Sarah Gentry, Juliet A. Usher-Smith
Feb 17, 2021
Background: A significant proportion of the worldwide population is at risk of social isolation and loneliness as a result of the COVID-19 pandemic. We aimed to identify effective interventions to reduce social isolation and...
The school policy, social, and physical environment and change in adolescent physical activity
Campbell Foubister, Esther M. F. van Sluijs, Anna Vignoles, Paul Wilkinson, Edward C. F. Wilson, Caroline H. D. Croxson, Helen Elizabeth Brown, Kirsten Corder
Apr 08, 2021
Purpose: We examined the association between the school policy, social and physical environment and change in adolescent physical activity (PA) and explored how sex and socioeconomic status modified potential associations....
80 questions for UK biological security
Luke Kemp, David C. Aldridge, Olaf Booy, Hilary Bower, Des Browne, Mark Burgmann, Austin Burt, Andrew A. Cunningham, Malcolm Dando, Jaimie T. A. Dick, Christopher Dye, Sam Weiss Evans, Belinda Gallardo, H. Charles J. Godfray, Ian Goodfellow, Simon Gubbins, Lauren A. Holt, Kate E. Jones, Hazem Kandil, Phillip Martin, Mark McCaughan, Caitríona McLeish, Thomas Meany, Kathryn Millett, Sean S. ÓhÉigeartaigh, Nicola J. Patron, Catherine Rhodes, Helen E. Roy, Gorm Shackelford, Derek Smith, Nicola Spence, Helene Steiner, Lalitha S. Sundaram, Silja Voeneky, John R. Walker, Harry Watkins, Simon Whitby, James Wood, William J. Sutherland
Jan 06, 2021
Evaluating the citywide Edinburgh 20mph speed limit intervention effects on traffic speed and volume
Glenna F Nightingale, Andrew James Williams, Ruth F Hunter, James Woodcock, Kieran Turner, Claire L Cleland, Graham Baker, Mike Kelly, Andy Cope, Frank Kee, Karen Milton, Charlie Foster, Ruth Jepson, Paul Kelly
Jan 07, 2022
OBJECTIVES: Traffic speed is important to public health as it is a major contributory factor to collision risk and casualty severity. 20mph (32km/h) speed limit interventions are an increasingly common approach to address this...
Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer
Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Douglas F. Easton, Jennifer G. McIntosh, Jon Emery, Marc Tischkowitz, Antonis C. Antoniou, Fiona M. Walter
Mar 06, 2020
Background: There is a growing focus on the development of multi-factorial cancer risk prediction algorithms alongside tools that operationalise them for clinical use. BOADICEA is a breast and ovarian cancer risk prediction...
Analysing the evolution of aerospace ecosystem development
Aerospace manufacturing industry is predicted to continue growing. Rising demand is triggering the current global aerospace ecosystem to evolve and adapt to challenges never faced before. New players into the aerospace...
Gene drives for schistosomiasis transmission control
Theresa Maier, Nicolas James Wheeler, Erica K. O. Namigai, Josh Tycko, Richard Ernest Grewelle, Yimtubezinash Woldeamanuel, Katharina Klohe, Javier Perez-Saez, Susanne H. Sokolow, Giulio A. De Leo, Timothy P. Yoshino, Mostafa Zamanian, Jutta Reinhard-Rupp
Dec 19, 2019
Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas....
Victims, offenders and victim-offender overlaps of knife crime
Knife crime is a source of concern for the police in England and Wales, however little published research exists on this crime type. Who are the offenders who use knives to commit crime, when and why? Who are their victims, and...
An integrative model of new product evaluation
The literature on perceived novelty and product evaluation has diverged into two disparate streams of research. The first stream builds on theories of curiosity and argues that the perceived novelty of a new product benefits...
Performance of early warning signals for disease re-emergence
Developing measures for rapid and early detection of disease re-emergence is important to perform science-based risk assessment of epidemic threats. In the past few years, several early warning signals (EWS) from complex systems...
Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells
Lavinia-Lorena Pruteanu, Liliya Kopanitsa, Dezső Módos, Edgars Kletnieks, Elena Samarova, Andreas Bender, Leonardo Dario Gomez, David Stanley Bailey
Sep 18, 2020
Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with...
ChronoMID—Cross-modal neural networks for 3-D temporal medical imaging data
ChronoMID—neural networks for temporally-varying, hence Chrono, Medical Imaging Data—makes the novel application of cross-modal convolutional neural networks (X-CNNs) to the medical domain. In this paper, we present multiple...
Anticipatory changes in British household purchases of soft drinks associated with the announcement of the Soft Drinks Industry Levy
David Pell, Tarra L. Penney, Oliver Mytton, Adam Briggs, Steven Cummins, Mike Rayner, Harry Rutter, Peter Scarborough, Stephen J. Sharp, Richard D. Smith, Martin White, Jean Adams
Nov 12, 2020
Background: Sugar-sweetened beverage (SSB) consumption is positively associated with obesity, type 2 diabetes, and cardiovascular disease. The World Health Organization recommends that member states implement effective taxes on...
A mathematical investigation into the uptake kinetics of nanoparticles in vitro
Hannah West, Fiona Roberts, Paul Sweeney, Simon Walker-Samuel, Joseph Leedale, Helen Colley, Craig Murdoch, Rebecca J. Shipley, Steven Webb
Jul 28, 2021
Nanoparticles have the potential to increase the efficacy of anticancer drugs whilst reducing off-target side effects. However, there remain uncertainties regarding the cellular uptake kinetics of nanoparticles which could have...
Number of days required to estimate physical activity constructs objectively measured in different age groups
Luiza Isnardi Cardoso Ricardo, Andrea Wendt, Leony Morgana Galliano, Werner de Andrade Muller, Gloria Izabel Niño Cruz, Fernando Wehrmeister, Soren Brage, Ulf Ekelund, Inácio Crochemore M. Silva
Jan 10, 2020
Purpose: The present study aims to estimate the minimum number of accelerometer measurement days needed to estimate habitual physical activity (PA) among 6- (2010), 18- (2011) and 30- (2012) year-old participants, belonging to...
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