Environmentally sensitive hotspots in the methylome of the early human embryo.
Matt J Silver,
Ayden Saffari,
Noah J Kessler,
Gririraj R Chandak,
Caroline HD Fall,
Prachand Issarapu,
Akshay Dedaniya,
Modupeh Betts,
Sophie E Moore,
Michael N Routledge,
Zdenko Herceg,
Cyrille Cuenin,
Maria Derakhshan,
Philip T James,
David Monk,
Andrew M Prentice
Mar 10, 2022
In humans, DNA methylation marks inherited from gametes are largely erased following fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of seasonal variation including changes in...