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Results: 7
Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1.
Daniel E Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M Thornton
Aug 13, 2020
BACKGROUND: Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process....
aging Biological age DNA Methylation Developmental disorder Epigenetic clock epigenetics H3K36 methylation Methylation entropy NSD1 Sotos syndrome Adult aging Biological Clocks CpG Islands DNA Methylation Entropy Epigenesis Genetic Genetic Testing Genome Human Histone-Lysine N-Methyltransferase Histones Humans Infant Lysine Models Genetic Sotos Syndrome
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey, John L. Hopper
Jan 23, 2021
Abstract: Background: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of...
Genetic and environmental causes of variation in epigenetic aging across the lifespan.
Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper
Oct 22, 2021
BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation....
aging Biological age DNA Methylation Epigenetic aging Epigenetic clock Twin study Adolescent Adult Aged Aged 80 and over aging Case-Control Studies Child Child Preschool DNA Methylation Epigenesis Genetic Epigenomics Female Gene-Environment Interaction genetic variation Genome-Wide Association Study Humans Infant Infant Newborn longevity Male Middle Aged Twins Dizygotic Twins Monozygotic Young Adult
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey, John L. Hopper
Oct 22, 2020
Abstract: Background: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of...
Cell and tissue type independent age-associated DNA methylation changes are not rare but common.
Age-associated DNA methylation changes have been widely reported across many different tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a surprisingly high degree of accuracy appear to do so...
Multi-tissue DNA methylation age predictor in mouse.
Thomas M Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik
Jun 28, 2019
BACKGROUND: DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an...
Correlation of an epigenetic mitotic clock with cancer risk.
Zhen Yang, Andrew Wong, Diana Kuh, Dirk S Paul, Vardhman K Rakyan, R David Leslie, Shijie C Zheng, Martin Widschwendter, Stephan Beck, Andrew E Teschendorff
Mar 26, 2018
BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be...
Ageing Cancer DNA Methylation Epigenetic clock Mitotic Stem Cells aging CpG Islands DNA Methylation Epigenesis Genetic Gene Expression Regulation Neoplastic High-Throughput Nucleotide Sequencing Humans Mitosis Mitotic Index Models Theoretical Neoplasms Neoplastic Stem Cells Polycomb-Group Proteins Promoter Regions Genetic