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An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Harry J Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S Howard, John Wharton, Benjamin Dunmore, Paul D Upton, Martin R Wilkins, Joshua B Edel, Beata Wojciak-Stothard
Dec 09, 2022
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell...