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Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults.
Paul Milne, Venetia Bigley, Chris M Bacon, Antoine Néel, Naomi McGovern, Simon Bomken, Muzlifah Haniffa, Eli L Diamond, Benjamin H Durham, Johannes Visser, David Hunt, Harsha Gunawardena, Mac Macheta, Kenneth L McClain, Carl Allen, Omar Abdel-Wahab, Matthew Collin
Mar 18, 2019
Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. BRAFV600E mutation is the most common mutation in both conditions and also...
Adult Alleles Antigens CD Antigens CD1 Bone Marrow Cells Cell Differentiation Dendritic Cells Diagnosis Differential Erdheim-Chester Disease Female foam cells Gene Expression Glycoproteins Granulocyte-Macrophage Colony-Stimulating Factor Hematopoietic Stem Cells Histiocytosis Langerhans-Cell Humans Immunophenotyping Lectins C-Type Lipopolysaccharide Receptors Male Mannose-Binding Lectins Monocytes Mutation Proto-Oncogene Proteins B-raf Receptors Notch Transforming Growth Factor beta