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The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia.
Halima Al Balushi, Kobina Dufu, David C Rees, John N Brewin, Anke Hannemann, Donna Oksenberg, David C-Y Lu, John S Gibson
Feb 28, 2019
GBT1118 O2 affinity sickle cell anemia cell volume Hemolysis Potassium permeability sickling Anemia Sickle Cell Antisickling Agents Benzaldehydes Cell Size Erythrocyte Membrane Hemoglobin Sickle Hemolysis Humans Intermediate-Conductance Calcium-Activated Potassium Channels Niacinamide Oxygen Permeability Symporters
Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia.
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.
Benjamin J Ravenhill, Usheer Kanjee, Ambroise Ahouidi, Luis Nobre, James Williamson, Jonathan M Goldberg, Robin Antrobus, Tandakha Dieye, Manoj T Duraisingh, Michael P Weekes
Aug 19, 2019
Red blood cells (RBCs) play a critical role in oxygen transport, and are the focus of important diseases including malaria and the haemoglobinopathies. Proteins at the RBC surface can determine susceptibility to disease, however...
The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion.
Viola Introini, Alejandro Marin-Menendez, Guilherme Nettesheim, Yen-Chun Lin, Silvia N Kariuki, Adrian L Smith, Letitia Jean, John N Brewin, David C Rees, Pietro Cicuta, Julian C Rayner, Bridget S Penman
Jun 29, 2022
Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the...