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PURPOSE: Genetic factors have been implicated in the pathogenesis of renal cell carcinoma (RCC), with around 3% of cases having a family history. A greater knowledge of the genetics of inherited RCC has the potential to...

Familial syndromic renal cancer Genetics von Hippel–Lindau review Age of Onset Birt-Hogg-Dube Syndrome Carcinoma Renal Cell Disease Management Early Detection of Cancer Fumarate Hydratase Humans Kidney Neoplasms Leiomyomatosis Neoplasms Multiple Primary Neoplastic Syndromes Hereditary Proto-Oncogene Proteins Proto-Oncogene Proteins c-met Skin Neoplasms Succinate Dehydrogenase Tumor Suppressor Proteins Ubiquitin Thiolesterase Uterine Neoplasms Von Hippel-Lindau Tumor Suppressor Protein von Hippel-Lindau Disease