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Results: 9
Parental depression and child outcomes--is marital conflict the missing link?
BACKGROUND: Both maternal and paternal depression during the perinatal period are associated with adverse effects on child outcomes. Attention has started to focus on the mechanisms mediating these relationships. Marital...
Psychological impact of family history risk assessment in primary care
BACKGROUND: Routine family history risk assessment for chronic diseases could enable primary care practitioners to efficiently identify at-risk patients and promote preventive management strategies. OBJECTIVES: To investigate...
A whole family-based physical activity promotion intervention
Justin M Guagliano, Sofie M Armitage, Helen Elizabeth Brown, Emma Coombes, Francesco Fusco, Claire Hughes, Andrew P Jones, Katie L Morton, Esther Mf van Sluijs
Oct 08, 2020
INTRODUCTION: This study assessed the feasibility and acceptability of FRESH (Families Reporting Every Step to Health), a theory-based child-led family physical activity (PA) intervention delivered online. We also assessed the...
Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.
James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh-Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brien
Jan 25, 2018
INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is...
Cerebral microbleed cerebral small vessel disease Dementia MRI Middle age Risk Factors White matter hyperintensity Adult Alzheimer Disease Apolipoprotein E4 cerebral small vessel diseases Cross-Sectional Studies Family Health Female Genetic Predisposition to Disease Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged prevalence Regression Analysis statistics Nonparametric white matter
Interaction between parental psychosis and early motor development and the risk of schizophrenia in a general population birth cohort.
E Keskinen, A Marttila, R Marttila, PB Jones, GK Murray, K Moilanen, H Koivumaa-Honkanen, P Mäki, M Isohanni, E Jääskeläinen, J Miettunen
Sep 25, 2015
Birth cohort Motor developmental milestone Parental psychosis Risk factor Schizophrenia Adult Child Child of Impaired Parents Cohort Studies Developmental Disabilities Family Health Female Finland Humans Infant Male Middle Aged Motor Skills Disorders Parents Prospective Studies Psychopathology Psychotic Disorders Risk Factors Schizophrenia
Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations
Bram P Prins, Karoline B Kuchenbaecker, Yanchun Bao, Melissa Smart, Delilah Zabaneh, Ghazaleh Fatemifar, Jian'an Luan, Nick J Wareham, Robert A Scott, John RB Perry, Claudia Langenberg, Michaela Benzeval, Meena Kumari, Eleftheria Zeggini
Dec 12, 2017
Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.
Sherly X Li, Roger L Milne, Tu Nguyen-Dumont, Xiaochuan Wang, Dallas R English, Graham G Giles, Melissa C Southey, Antonis C Antoniou, Andrew Lee, Shuai Li, Ingrid Winship, John L Hopper, Mary Beth Terry, Robert J Macinnis
Feb 24, 2021
BACKGROUND: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals...
Adult Aged Algorithms Breast Neoplasms Confidence Intervals Family Health Female Genetic Predisposition to Disease genetic variation Humans Life Style Medical History Taking Middle Aged Models Statistical Polymorphism Single Nucleotide Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Time Factors
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.
Lisa M Maier, Deborah J Smyth, Adrian Vella, Felicity Payne, Jason D Cooper, Rebecca Pask, Christopher Lowe, John Hulme, Luc J Smink, Heather Fraser, Carolyn Moule, Kara M Hunter, Giselle Chamberlain, Neil Walker, Sarah Nutland, Dag E Undlien, Kjersti S Rønningen, Cristian Guja, Constantin Ionescu-Tîrgoviste, David A Savage, David P Strachan, Laurence B Peterson, John A Todd, Linda S Wicker, Rebecca C Twells
Jun 14, 2011
Correcting for bias in the selection and validation of informative diagnostic tests.
When developing a new diagnostic test for a disease, there are often multiple candidate classifiers to choose from, and it is unclear if any will offer an improvement in performance compared with current technology. A two-stage...
Diagnostic Tests family history group sequential design uniformly minimum variance unbiased estimator Analysis of Variance Bias Biomarkers Breast Neoplasms Computer Simulation Confidence Intervals Early Detection of Cancer Epidemiologic Research Design Family Health Female Humans Likelihood Functions Reproducibility of Results Risk Assessment statistics Nonparametric Surveys and Questionnaires