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Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the...

Familywise error-rate group sequential interim analyses Multi-arm multi-stage t-Statistic Analysis of Variance Clinical Trials as Topic Data Interpretation Statistical Endpoint Determination Humans Monte Carlo Method Research Design Sample Size

BACKGROUND: Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has been argued...

False discovery rate Familywise error-rate Multiple comparisons optimal design power Sample Size Clinical Trials as Topic Data Interpretation Statistical Humans Research Design Sample Size Software Web Browser

Abstract: Background: Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has...

Software Experimental therapeutics and drug development False discovery rate Familywise error-rate Multiple comparisons optimal design power Sample Size