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An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.
Nga Tran Vu Thieu, Tan Trinh Van, Anh Tran Tuan, Elizabeth J Klemm, Chau Nguyen Ngoc Minh, Phat Voong Vinh, Duy Pham Thanh, Thanh Ho Ngoc Dan, Trung Pham Duc, Pinky Langat, Laura B Martin, Jorge Galan, Li Liang, Philip L Felgner, D Huw Davies, Hanna K de Jong, Rapeephan R Maude, Masako Fukushima, Lalith Wijedoru, Aniruddha Ghose, Rasheda Samad, Arjen M Dondorp, Abul Faiz, Thomas C Darton, Andrew J Pollard, Guy E Thwaites, Gordon Dougan, Christopher M Parry, Stephen Baker
Apr 10, 2019
OBJECTIVES: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of...
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.
Thomas C Darton, Liqing Zhou, Christoph J Blohmke, Claire Jones, Claire S Waddington, Stephen Baker, Andrew J Pollard
Apr 10, 2019
BACKGROUND: Improved diagnostics for typhoid are needed; a typhoid controlled human infection model may accelerate their development and translation. Here, we evaluated a blood culture-PCR assay for detecting infection after...
controlled human infection model Diagnostics Febrile disease Polymerase Chain Reaction Salmonella typhi Typhoid Fever Adolescent Adult Asymptomatic Infections Bacteremia blood culture Culture Media DNA Bacterial Female Fever Healthy Volunteers Humans Male Middle Aged Polymerase Chain Reaction Salmonella typhi Sensitivity and Specificity Typhoid Fever Young Adult