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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Rachel H Clare, Catherine Bardelle, Paul Harper, W David Hong, Ulf Börjesson, Kelly L Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren AN Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L Nixon, Barton E Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G Berry, Paul M O'Neill, Mark J Taylor, Stephen A Ward
Feb 25, 2019
Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of...