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Para-chloro-2-[18F]fluoroethyl-etomidate
Isabella Silins, Anders Sundin, Patrik Nordeman, Mahabuba Jahan, Sergio Estrada, Azita Monazzam, Mark Lubberink, Franklin Aigbirhio, Per Hellman, Gunnar Antoni
May 21, 2021
Introduction: [11C]Metomidate ([11C]MTO), the methyl ester analogue of etomidate, was developed as a positron emission tomography (PET) radiotracer for adrenocortical tumours and has also been suggested for imaging in primary...
18F-CETO Adrenal masses Adrenal tracer positron emission tomography primary aldosteronism Adrenal Cortex Adrenal Cortex Neoplasms Animals Drug Evaluation Preclinical Etomidate Fluorine Radioisotopes Humans hyperaldosteronism Macaca fascicularis Mice Positron-Emission Tomography Radiopharmaceuticals Rats Tissue Distribution
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors HW Scheres, Michel Goedert
Aug 02, 2021
Tau and Aβ assemblies of Alzheimer's disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is...
Alzheimer’s disease Electron cryo-microscopy Immunopurification positron emission tomography Posterior cortical atrophy Primary age-related tauopathy Aged Aged 80 and over Alzheimer Disease Benzothiazoles Binding Sites Cryoelectron Microscopy Female Fluorine Radioisotopes Humans Ligands Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals tau Proteins
Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.
Elijah Mak, Nicolas Nicastro, Maura Malpetti, George Savulich, Ajenthan Surendranathan, Negin Holland, Luca Passamonti, P Simon Jones, Stephen F Carter, Li Su, Young T Hong, Tim D Fryer, Guy B Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
Nov 17, 2020
Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of...
Amyloid Dementia Lewy Bodies Neuroinflammation Tau Aged Aged 80 and over Carbolines Female Fluorine Radioisotopes Humans Inflammation Lewy Body Disease Male Microglia Middle Aged Phenotype Positron-Emission Tomography Radioisotopes Radiopharmaceuticals Severity of Illness Index Temporal Lobe tau Proteins
Radiosynthesis of (R,S)-[18 F]GE387
Luxi Qiao, Emily Fisher, Lindsay McMurray, Selena Milicevic Sephton, Matthew Hird, Nisha Kuzhuppilly-Ramakrishnan, David J Williamson, Xiouyun Zhou, Eryn Werry, Michael Kassiou, Saijinder Luthra, William Trigg, Franklin I Aigbirhio
Apr 01, 2019
Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.
Agnese Irkle, Alex T Vesey, David Y Lewis, Jeremy N Skepper, Joseph LE Bird, Marc R Dweck, Francis R Joshi, Ferdia A Gallagher, Elizabeth A Warburton, Martin R Bennett, Kevin M Brindle, David E Newby, James H Rudd, Anthony P Davenport
Jun 03, 2015
Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides).
Alessandra Cavaliere, Katrin C Probst, Stephen J Paisey, Christopher Marshall, Abdul KH Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D Westwell
Apr 24, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success....