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Mass spectrometry for fragment screening.
Fragment-based approaches in chemical biology and drug discovery have been widely adopted worldwide in both academia and industry. Fragment hits tend to interact weakly with their targets, necessitating the use of sensitive...
Fragment-based drug discovery ligand-observed mass spectrometry native mass spectrometry Calorimetry Combinatorial Chemistry Techniques Crystallography X-Ray Drug Design Drug Discovery Fluorometry High-Throughput Screening Assays Humans Ligands Magnetic Resonance Spectroscopy Mass Spectrometry Protein Binding Proteins Small Molecule Libraries Structure-Activity Relationship