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GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain.
Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing...
brain plasticity Functional MRI human Magnetic Resonance Spectroscopy neuroscience visual learning Adult Female GABAergic Neurons Humans learning Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Neural Inhibition Neuronal Plasticity Occipital Lobe Perception Temporal Lobe Young Adult gamma-Aminobutyric Acid
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Andreas Bruzelius, Srisaiyini Kidnapillai, Janelle Drouin-Ouellet, Tom Stoker, Roger A Barker, Daniella Rylander Ottosson
Jan 28, 2022
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling....
adult skin cells calbindin direct reprogramming disease-modelling Electrophysiology iN neuronal conversion Adult Brain Diseases Cell Differentiation Cellular Reprogramming Cognitive Dysfunction FIBROBLASTS GABAergic Neurons Gene Expression Regulation Humans Interneurons Neurogenesis Neuroglia Repressor Proteins Skin gamma-Aminobutyric Acid
Selective Inhibition Mediates the Sequential Recruitment of Motor Pools.
Maarten F Zwart, Stefan R Pulver, James W Truman, Akira Fushiki, Richard D Fetter, Albert Cardona, Matthias Landgraf
Jul 05, 2016
Hierarchical neural architecture underlying thirst regulation.
Vineet Augustine, Sertan Kutal Gokce, Sangjun Lee, Bo Wang, Thomas J Davidson, Frank Reimann, Fiona Gribble, Karl Deisseroth, Carlos Lois, Yuki Oka
May 25, 2018
Neural circuits for appetites are regulated by both homeostatic perturbations and ingestive behaviour. However, the circuit organization that integrates these internal and external stimuli is unclear. Here we show in mice that...
Identification of visual cortex cell types and species differences using single-cell RNA sequencing.
Jia-Ru Wei, Zhao-Zhe Hao, Chuan Xu, Mengyao Huang, Lei Tang, Nana Xu, Ruifeng Liu, Yuhui Shen, Sarah A Teichmann, Zhichao Miao, Sheng Liu
Jan 05, 2023
The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul Jp Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A Barker, Massimiliano Pagani, Elena Cattaneo
May 10, 2021
Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of...
Propofol sedation-induced alterations in brain connectivity reflect parvalbumin interneurone distribution in human cerebral cortex.
Michael M Craig, Bratislav Misic, Ioannis Pappas, Ram M Adapa, David K Menon, Emmanuel A Stamatakis
Dec 14, 2020
GABAergic interneurone Default mode network frontoparietal control network functional connectivity Gene Expression parvalbumin Propofol Adult Brain Cerebral Cortex Female GABAergic Neurons Humans Hypnotics and Sedatives Interneurons Magnetic Resonance Imaging Male Middle Aged Nerve Net Parvalbumins Propofol Protein Array Analysis
In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors.
Rachel E Shaw, Benjamin Kottler, Zoe N Ludlow, Edgar Buhl, Dongwook Kim, Sara Morais da Silva, Alina Miedzik, Antoine Coum, James JL Hodge, Frank Hirth, Rita Sousa-Nunes
Sep 08, 2018
A central hypothesis for brain evolution is that it might occur via expansion of progenitor cells and subsequent lineage-dependent formation of neural circuits. Here, we report in vivo amplification and functional integration of...