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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Olga Rudenko, Jin Shang, Alexander Munk, Jeppe P Ekberg, Natalia Petersen, Maja S Engelstoft, Kristoffer L Egerod, Siv A Hjorth, Margaret Wu, Yue Feng, Yun-Ping Zhou, Jacek Mokrosinski, Peter Thams, Frank Reimann, Fiona Gribble, Jens F Rehfeld, Jens J Holst, Jonas T Treebak, Andrew D Howard, Thue W Schwartz
Apr 05, 2019
OBJECTIVES: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. METHODS AND...
amino acid sensing G-protein-coupled receptor GPR142 Glucose homeostasis Trp Amino Acids Aromatic Animals Blood Glucose Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Glucagon-Secreting Cells Glucose Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Knockout Mice Obese Rats Rats Zucker Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Receptors Glucagon Tryptophan