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The discovery and maturation of peptide biologics targeting the small G protein Cdc42
George JN Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott, R Neil Cooley, Darerca Owen
Jan 23, 2020
Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins