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Cell Cycle Checkpoints Cells Cultured Enzyme Activation Fluorescent Antibody Technique Gene Amplification Genome Viral Human papillomavirus 16 Human papillomavirus 18 Humans Immunoblotting Immunohistochemistry In Situ Hybridization Fluorescence Keratinocytes Life Cycle Stages Mutagenesis Site-Directed Oncogene Proteins Viral Real-Time Polymerase Chain Reaction Virus Replication

BACKGROUND & AIMS: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about...

antitumor immune response gene repression prognostic factor response to treatment Adenocarcinoma Aged Antineoplastic Agents Barrett Esophagus Cyclin E DNA Methylation Disease Progression Epigenesis Genetic Esophageal Mucosa Esophageal Neoplasms Female Gene Amplification Gene Expression Regulation Neoplastic Humans Male Middle Aged Oncogene Proteins Promoter Regions Genetic RNA-seq Retrospective Studies Temozolomide whole genome sequencing

BACKGROUND: MYCN amplification (MNA) is the strongest indicator of poor prognosis in neuroblastoma (NB). This meta-analysis aims to determine the diagnostic accuracy of MNA analysis in circulating-free DNA (cfDNA) from...

Cell-Free Nucleic Acids Gene Amplification Humans N-Myc Proto-Oncogene Protein Neoplasm Staging Neuroblastoma

Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation....

Leishmania Aneuploidy evolution gene copy number variation genomic adaptation telomeric amplification Adaptation Physiological Animals Chromosomes Cricetinae DNA Copy Number Variations Dogs evolution Molecular Gene Amplification Gene Dosage Gene Expression Regulation Genes Protozoan Genetic Fitness Genome Protozoan Genomics High-Throughput Nucleotide Sequencing Humans Karyotype Leishmania donovani Leishmaniasis Visceral Telomere

BACKGROUND: The ASCO/CAP guidance on HER2 testing in breast cancer (BC) has recently changed. Group 2 tumours with immunohistochemistry score 2+ and HER2/CEP17 ratio ≥2.0 and HER2 copy number <4.0 signals/cell were re-classified...

Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Breast Neoplasms Case-Control Studies Cohort Studies Female Gene Amplification Gene Dosage Humans Immunohistochemistry In Situ Hybridization Fluorescence Neoadjuvant Therapy Neoplasm Grading Receptor ErbB-2 Retrospective Studies

Transcription Translation Cell Cycle oncogene Mrna Processing Aurora Kinase A Cell Line Tumor Animals Mammals Humans Cell Cycle Gene Amplification Gene Expression Regulation Neoplastic

BACKGROUND: Complex clusters of rearrangements are a challenge in interpretation of cancer genomes. Some clusters of rearrangements demarcate clear amplifications of driver oncogenes but others are less well understood. A...

Adult Age Distribution Aged Aged 80 and over Algorithms Breast Breast Neoplasms Carrier Proteins Chromosomes Human Pair 11 Chromosomes Human Pair 8 Cyclin D1 Datasets as Topic Female Gene Amplification Genetic Loci Genomics Humans Middle Aged Oncogenes Receptor Fibroblast Growth Factor Type 1 Translocation Genetic whole genome sequencing

Animals Codon Nonsense DNA Repeat Expansion Gene Amplification Male Multigene Family Short Interspersed Nucleotide Elements Sus scrofa Swine Testis Transcription Factors Y Chromosome

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even...

Animals Animals Genetically Modified DNA Copy Number Variations Disease Models Animal Gene Amplification Gene Knockout Techniques Genetic Heterogeneity Homozygote INDEL Mutation Melanoma Mutation Polymorphism Single Nucleotide Risk Factors Sequence Deletion Ultraviolet Rays Zebrafish

BACKGROUND AND AIMS: Chromosome 17 alterations affect the assessment of HER2 gene amplification in breast cancer (BC), but its clinical significance remains unclear. This study aimed to identify the prevalence of centromere...

CEP17 chromosome 17 HER2 alterations Breast Cancer Breast Neoplasms Centromere Chromosome Aberrations Chromosomes Human Pair 17 Female Gene Amplification Humans Immunohistochemistry In Situ Hybridization Fluorescence Receptor ErbB-2

BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents....

Breast Cancer Mitotic Index Novel therapeutics Predictive biomarker Aurora Kinases Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Cell Proliferation Chromosomal Proteins Non-Histone Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genome Human Humans Kaplan-Meier Estimate Mitosis Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins RNA Interference Small Molecule Libraries Treatment Outcome

HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene...

Breast Neoplasms DNA Copy Number Variations Estrogen Receptor alpha Female Gene Amplification Gene Expression Profiling Humans Mutation Polymorphism Single Nucleotide Receptor ErbB-2 Receptors Progesterone Transcriptome whole genome sequencing

To date, characterization of ancient oral (dental calculus) and gut (coprolite) microbiota has been primarily accomplished through a metataxonomic approach involving targeted amplification of one or more variable regions in the...

Archaeology Bacteria Dental Calculus Female Gastrointestinal Microbiome Gene Amplification High-Throughput Nucleotide Sequencing Humans Male Metagenome Metagenomics Methanobrevibacter Microbiota Nucleic Acid Conformation Phylogeny RNA Ribosomal 16S

BACKGROUND: FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution...

FGFR1 amplification FGFR1 overexpression Luminal breast cancer palbociclib Rogaratinib Adult Aged Aged 80 and over Antineoplastic Agents Biomarkers Tumor Breast Neoplasms Cell Line Tumor Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Disease Management Disease Susceptibility Drug Resistance Multiple Drug Resistance Neoplasm Female Gene Amplification Gene Expression Humans In Situ Hybridization Fluorescence Middle Aged Molecular Targeted Therapy Neoplasm Staging Prognosis RNA Messenger Receptor Fibroblast Growth Factor Type 1 Receptors Estrogen Treatment Outcome Young Adult

Aurora Kinase A Cell Cycle Mrna Processing oncogene Transcription Translation Animals Aurora Kinase A Cell Cycle Cell Line Tumor Gene Amplification Gene Expression Regulation Neoplastic Humans Mammals