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Results: 54
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Jacinta I Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E Harris, Helena Rodriguez-Caro, Aimée Jacquemot, Jack J Miller, Eleanor M Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth MC Fisher, Victor LJ Tybulewicz, Timothy J Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B Sparrow
Jul 28, 2021
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero...
Animals Aorta Thoracic Biomarkers cardiovascular system Cell Differentiation Coronary Vessels Dietary Supplements Edema Embryo Mammalian Embryonic Development Female Gene Expression Profiling Gene-Environment Interaction Green Fluorescent Proteins Iron Iron Deficiencies Lymphatic Vessels Mice Inbred C57BL Myocardium Myocytes Cardiac Penetrance Phenotype Pregnancy Signal Transduction Stem Cells Transgenes Tretinoin
The genetics of obesity
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct...
Long-term physical activity
Ceryl A Harwood, Kate Westgate, Sue Gunstone, Soren Brage, Nicholas J Wareham, Christopher J McDermott, Pamela J Shaw
Apr 13, 2016
Amyotrophic Lateral Sclerosis EPIDEMIOLOGY Gene-Environment Interaction physical activity Risk factor Adult Aged Aged 80 and over Amyotrophic Lateral Sclerosis Case-Control Studies Exercise Female Humans Longitudinal Studies Male Middle Aged Odds Ratio Retrospective Studies Risk Factors Surveys and Questionnaires United Kingdom
Recent genetic connectivity and clinal variation in chimpanzees.
Jack D Lester, Linda Vigilant, Paolo Gratton, Maureen S McCarthy, Christopher D Barratt, Paula Dieguez, Anthony Agbor, Paula Álvarez-Varona, Samuel Angedakin, Emmanuel Ayuk Ayimisin, Emma Bailey, Mattia Bessone, Gregory Brazzola, Rebecca Chancellor, Heather Cohen, Emmanuel Danquah, Tobias Deschner, Villard Ebot Egbe, Manasseh Eno-Nku, Annemarie Goedmakers, Anne-Céline Granjon, Josephine Head, Daniela Hedwig, R Adriana Hernandez-Aguilar, Kathryn J Jeffery, Sorrel Jones, Jessica Junker, Parag Kadam, Michael Kaiser, Ammie K Kalan, Laura Kehoe, Ivonne Kienast, Kevin E Langergraber, Juan Lapuente, Anne Laudisoit, Kevin Lee, Sergio Marrocoli, Vianet Mihindou, David Morgan, Geoffrey Muhanguzi, Emily Neil, Sonia Nicholl, Christopher Orbell, Lucy Jayne Ormsby, Liliana Pacheco, Alex Piel, Martha M Robbins, Aaron Rundus, Crickette Sanz, Lilah Sciaky, Alhaji M Siaka, Veronika Städele, Fiona Stewart, Nikki Tagg, Els Ton, Joost van Schijndel, Magloire Kambale Vyalengerera, Erin G Wessling, Jacob Willie, Roman M Wittig, Yisa Ginath Yuh, Kyle Yurkiw, Klaus Zuberbuehler, Christophe Boesch, Hjalmar S KÜhl, Mimi Arandjelovic
Mar 05, 2021
Divergence of regulatory networks governed by the orthologous transcription factors FLC and PEP1 in Brassicaceae species.
Julieta L Mateos, Vicky Tilmes, Pedro Madrigal, Edouard Severing, René Richter, Colin WM Rijkenberg, Paweł Krajewski, George Coupland
Jun 19, 2020
Genome-wide landscapes of transcription factor (TF) binding sites (BSs) diverge during evolution, conferring species-specific transcriptional patterns. The rate of divergence varies in different metazoan lineages but has not...
Arabidopsis Arabis alpina binding-site evolution flowering vernalization Arabidopsis Proteins Binding Sites Brassicaceae Environment Flowers Gene Expression Regulation Plant Gene Regulatory Networks Gene-Environment Interaction genetic variation MADS Domain Proteins Nucleotide Motifs Plant Proteins Protein Binding Sequence Analysis DNA Transcription Factors
Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study
Hannah E Jongsma, Charlotte Gayer-Anderson, Antonio Lasalvia, Diego Quattrone, Alice Mulè, Andrei Szöke, Jean-Paul Selten, Caitlin Turner, Celso Arango, Ilaria Tarricone, Domenico Berardi, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Julio Bobes, Miguel bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Robin M Murray, Bart P Rutten, Peter B Jones, Jim van Os, Craig Morgan, James B Kirkbride, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2 (EU-GEI WP2) Group
Feb 08, 2018
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers
Theresia M. Schnurr, Emil Jørsboe, Alexandra Chadt, Inger K. Dahl-Petersen, Jonas M. Kristensen, Jørgen F. P. Wojtaszewski, Christian Springer, Peter Bjerregaard, Søren Brage, Oluf Pedersen, Ida Moltke, Niels Grarup, Hadi Al-Hasani, Anders Albrechtsen, Marit E. Jørgensen, Torben Hansen
Jul 01, 2021
Mapping gene by early life stress interactions on child subcortical brain structures
Koen Bolhuis, Rosa H Mulder, Casper Louk de Mol, Serena Defina, Varun Warrier, Tonya White, Henning Tiemeier, Ryan L Muetzel, Charlotte A M Cecil
Mar 16, 2023
Background
Although it is well-established that both genetics and the environment influence brain development, they are typically examined separately. Here, we aimed to prospectively investigate the interactive effects...
Published by: JCPP advances
The role of global and regional DNA methylation and histone modifications in glycemic traits and type 2 diabetes
T Muka, J Nano, T Voortman, KVE Braun, S Ligthart, S Stranges, WM Bramer, J Troup, R Chowdhury, A Dehghan, OH Franco
Nov 22, 2017
BACKGROUND: New evidence suggests the potential involvement of epigenetic mechanisms in type 2 diabetes (T2D) as a crucial interface between the effects of genetic predisposition and environmental influences. AIM: To...
epigenetics Global DNA methylation Glucose Histone modification Insulin Insulin Resistance Type 2 diabetes Acetylation Biomarkers Blood Glucose Chromatin Assembly and Disassembly DNA Methylation Diabetes mellitus Type 2 Epigenesis Genetic Female Gene Expression Regulation Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Histones Humans Insulin Insulin Resistance Male Phenotype Risk Factors
Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.
Michelle L Holland, Robert Lowe, Paul W Caton, Carolina Gemma, Guillermo Carbajosa, Amy F Danson, Asha AM Carpenter, Elena Loche, Susan E Ozanne, Vardhman K Rakyan
Aug 08, 2016
An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.
Elizabeth J Radford, Elvira Isganaitis, Josep Jimenez-Chillaron, Joshua Schroeder, Michael Molla, Simon Andrews, Nathalie Didier, Marika Charalambous, Kirsten McEwen, Giovanna Marazzi, David Sassoon, Mary-Elizabeth Patti, Anne C Ferguson-Smith
Dec 02, 2020
Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms...
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M Conroy, Patricia A Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R Teras, Alpa V Patel, Fergus J Couch, Janet E Olson, Elinor J Sawyer, Rebecca Roylance, Stig E Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guénel, Thérèse Truong, Renske Keeman, Marjanka K Schmidt, Anna H Wu, Chiu-Chen Tseng, Angela Cox, Simon S Cross, kConFab Investigators, Irene L Andrulis, John L Hopper, Melissa C Southey, Pei-Ei Wu, Chen-Yang Shen, Peter A Fasching, Arif B Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E Jones, Anthony J Swerdlow, Reiner Hoppe, Yon-Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M Hartikainen, Javier Benitez, Anna González-Neira, Christopher A Haiman, Thilo Dörk, Natalia V Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N Kristensen, NBCS Collaborators, Rob AEM Tollenaar, Bernadette AM Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V Lacey, Maria Elena Martinez, Alison M Dunning, Paul DP Pharoah, Douglas F Easton, Keun-Young Yoo, Daehee Kang
May 13, 2021
In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast...
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.
Theresia M Schnurr, Emil Jørsboe, Alexandra Chadt, Inger K Dahl-Petersen, Jonas M Kristensen, Jørgen FP Wojtaszewski, Christian Springer, Peter Bjerregaard, Søren Brage, Oluf Pedersen, Ida Moltke, Niels Grarup, Hadi Al-Hasani, Anders Albrechtsen, Marit E Jørgensen, Torben Hansen
May 03, 2021
AIMS/HYPOTHESIS: The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose...
Arctic Gene-Environment Interaction Lifestyle therapy physical activity Postprandial hyperglycaemia TBC1D4 loss-of-function Adult Blood Glucose Diabetes mellitus Type 2 Exercise Female GTPase-Activating Proteins Gene-Environment Interaction Genetic Predisposition to Disease Genotyping Techniques Glucose Tolerance Test Greenland Humans Hyperglycemia Insulin Inuit Life Style Loss of Function Mutation Male Middle Aged Postprandial Period
Mediation and modification of genetic susceptibility to obesity by eating behaviors.
Blandine de Lauzon-Guillain, Emma Ad Clifton, Felix R Day, Karine Clément, Soren Brage, Nita G Forouhi, Simon J Griffin, Yves Akoli Koudou, Véronique Pelloux, Nicholas J Wareham, Marie-Aline Charles, Barbara Heude, Ken K Ong
Aug 29, 2017
BMI Body Mass Index dieting eating behavior genetic risk score Genetics obesity Adult Appetite Body Mass Index Cognition Eating Emotions Feeding Behavior Female Gene-Environment Interaction Genetic Predisposition to Disease Humans Hyperphagia Male Middle Aged obesity Risk Factors self-control Sex Factors Surveys and Questionnaires
Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design
GS Dite, RJ MacInnis, A Bickerstaffe, JG Dowty, RL Milne, AC Antoniou, P Weideman, C Apicella, GG Giles, MC Southey, MA Jenkins, K-A Phillips, AK Win, MB Terry, JL Hopper
Mar 23, 2017
No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior.
Elizabeth C Braithwaite, Paul G Ramchandani, Thomas G O'Connor, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg, Vivette Glover, Elena Netsi, Jonathan Evans, Michael J Meaney, Susannah E Murphy
Dec 08, 2020
OBJECTIVE: Maternal antenatal anxiety is associated with an increased risk of behavioral disturbances in offspring. Recent work has suggested that the effect of maternal antenatal anxiety on infant temperament at 6 months is...
Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health
Varun Warrier, Alex SF Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte AM Cecil
Dec 21, 2020
Genetic and environmental causes of variation in epigenetic aging across the lifespan.
Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper
Oct 22, 2021
BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation....
aging Biological age DNA Methylation Epigenetic aging Epigenetic clock Twin study Adolescent Adult Aged Aged 80 and over aging Case-Control Studies Child Child Preschool DNA Methylation Epigenesis Genetic Epigenomics Female Gene-Environment Interaction genetic variation Genome-Wide Association Study Humans Infant Infant Newborn longevity Male Middle Aged Twins Dizygotic Twins Monozygotic Young Adult
Mapping gene by early life stress interactions on child subcortical brain structures
Koen Bolhuis, Rosa H Mulder, Casper Louk de Mol, Serena Defina, Varun Warrier, Tonya White, Henning Tiemeier, Ryan L Muetzel, Charlotte AM Cecil
Nov 17, 2022
BACKGROUND: Although it is well-established that both genetics and the environment influence brain development, they are typically examined separately. Here, we aimed to prospectively investigate the interactive effects of...
5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents
Nicholas D Walsh, Tim Dalgleish, Valerie J Dunn, Rosemary Abbott, Michelle C St Clair, Matthew Owens, Graeme Fairchild, William S Kerslake, Lucy V Hiscox, Luca Passamonti, Michael Ewbank, Maria Ban, Andrew J Calder, Ian M Goodyer
Nov 15, 2012
It is not known how 5-HTTLPR genotype x childhood adversity (CA) interactions that are associated with an increased risk for affective disorders in population studies operate at the neural systems level. We hypothesized that...
Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis
Hannah E Jongsma, Charlotte Gayer-Anderson, Ilaria Tarricone, Eva Velthorst, Els van der Ven, Diego Quattrone, Marta Di Forti, EU-GEI WP2 Group, Paulo Rossi Menezes, Christina Marta Del-Ben, Celso Arango, Antonio Lasalvia, Domenico Berardi, Caterina La Cascia, Julio Bobes, Miguel bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Lieuwe de Haan, Andrea Tortelli, Andrei Szöke, Robin M Murray, Bart P Rutten, Jim van Os, Craig Morgan, Peter B Jones, James B Kirkbride
Feb 18, 2020
discrimination EPIDEMIOLOGY Ethnicity Psychotic Disorders social disadvantage Adolescent Adult Black People Case-Control Studies Communication Barriers Ethnic and Racial Minorities Ethnicity Europe Female Gene-Environment Interaction Health Status Disparities Humans Male Middle Aged Odds Ratio Psychotic Disorders Schizophrenia Social Determinants of Health White People Young Adult
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia
Qiao Fan, Xiaobo Guo, J Willem L Tideman, Katie M Williams, Seyhan Yazar, S Mohsen Hosseini, Laura D Howe, Beaté St Pourcain, David M Evans, Nicholas J Timpson, George McMahon, Pirro G Hysi, Eva Krapohl, Ya Xing Wang, Jost B Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L Young, Olavi Pärssinen, Konrad Oexle, Norbert Pfeiffer, Joan E Bailey-Wilson, Andrew D Paterson, Caroline CW Klaver, Robert Plomin, Christopher J Hammond, David A Mackey, Mingguang He, Seang-Mei Saw, Cathy Williams, Jeremy A Guggenheim, CREAM Consortium
Aug 03, 2018
Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here...
Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis
B Pignon, H Peyre, A Ayrolles, JB Kirkbride, S Jamain, A Ferchiou, JR Richard, G Baudin, S Tosato, H Jongsma, L de Haan, I Tarricone, M Bernardo, E Velthorst, M Braca, C Arango, M Arrojo, J Bobes, CM Del-Ben, M Di Forti, C Gayer-Anderson, PB Jones, C La Cascia, A Lasalvia, PR Menezes, D Quattrone, J Sanjuán, JP Selten, A Tortelli, PM Llorca, J van Os, BPF Rutten, RM Murray, C Morgan, M Leboyer, A Szöke, F Schürhoff
Oct 28, 2022
AIMS: Gene x environment (G×E) interactions, i.e. genetic modulation of the sensitivity to environmental factors and/or environmental control of the gene expression, have not been reliably established regarding aetiology of...
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