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Results: 724
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Circulating vitamin D concentrations and risk of breast and prostate cancer
Xia Jiang, Niki L Dimou, Kawthar Al-Dabhani, Sarah J Lewis, Richard M Martin, Philip C Haycock, Marc J Gunter, Timothy J Key, Rosalind A Eeles, Kenneth Muir, David Neal, Graham G Giles, Edward L Giovannucci, Meir Stampfer, Brandon L Pierce, Joellen M Schildkraut, Shaneda Warren Andersen, Deborah Thompson, Wei Zheng, Peter Kraft, Konstantinos K Tsilidis, CRUK, BPC3, CAPS and PEGASUS consortia PRACTICAL
Apr 26, 2018
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR)...
Mendelian randomization Breast malignancy Prostate serum vitamin D concentrations Aged Breast Neoplasms Causality Female Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Prostatic Neoplasms Receptors Estrogen Risk Factors vitamin D
Gene exchange drives the ecological success of a multi-host bacterial pathogen.
Emily J Richardson, Rodrigo Bacigalupe, Ewan M Harrison, Lucy A Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul A Hoskisson, Matthew TG Holden, Edward J Feil, Gavin K Paterson, Steven YC Tong, Adebayo Shittu, Willem van Wamel, David M Aanensen, Julian Parkhill, Sharon J Peacock, Jukka Corander, Mark Holmes, J Ross Fitzgerald
Sep 29, 2018
The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and...
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.
Claudia Giambartolomei, Damjan Vukcevic, Eric E Schadt, Lude Franke, Aroon D Hingorani, Chris Wallace, Vincent Plagnol
Oct 03, 2018
Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases and traits, in particular cardiovascular...
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Sjur Reppe, Yunpeng Wang, Wesley K Thompson, Linda K McEvoy, Andrew J Schork, Verena Zuber, Marissa LeBlanc, Francesco Bettella, Ian G Mills, Rahul S Desikan, Srdjan Djurovic, Kaare M Gautvik, Anders M Dale, Ole A Andreassen, GEFOS Consortium
Mar 11, 2019
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but...
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Hailiang Huang, Ming Fang, Luke Jostins, Maša Umićević Mirkov, Gabrielle Boucher, Carl A Anderson, Vibeke Andersen, Isabelle Cleynen, Adrian Cortes, François Crins, Mauro D'Amato, Valérie Deffontaine, Julia Dmitrieva, Elisa Docampo, Mahmoud Elansary, Kyle Kai-How Farh, Andre Franke, Ann-Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, Ian C Lawrance, Charlie W Lees, Edouard Louis, Rob Mariman, Theo Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, Severine Vermeire, Ramnik J Xavier, International Inflammatory Bowel Disease Genetics Consortium, Rinse K Weersma, Richard H Duerr, Christopher G Mathew, John D Rioux, Dermot PB McGovern, Judy H Cho, Michel Georges, Mark J Daly, Jeffrey C Barrett
Mar 19, 2019
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few...
Adolescent Adult Aged Aged 80 and over Binding Sites Chromatin Colitis Ulcerative Crohn Disease Epigenesis Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotype Humans Inflammatory Bowel Diseases Linkage Disequilibrium Male Middle Aged Quantitative Trait Loci Smad3 Protein Transcription Factors Young Adult
Tensorial blind source separation for improved analysis of multi-omic data.
There is an increased need for integrative analyses of multi-omic data. We present and benchmark a novel tensorial independent component analysis (tICA) algorithm against current state-of-the-art methods. We find that tICA...
Cancer dimensional reduction Epigenome-wide association study Independent Component Analysis Multi-omic Tensor mQTL Algorithms DNA Copy Number Variations DNA Methylation Epigenesis Genetic Epigenomics Gene Expression Regulation Neoplastic Genetic Markers Genome-Wide Association Study Humans Neoplasms Quantitative Trait Loci
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes CA Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
Sep 05, 2018
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain...
cerebral small vessel diseases Diffusion tensor imaging Genetic Association Studies Humans white matter Adult Aged Biological Specimen Banks cerebral small vessel diseases Dementia Depression Depressive Disorder Major Diffusion Magnetic Resonance Imaging Female Genome-Wide Association Study Humans Male Middle Aged stroke United Kingdom white matter
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
Jordi Merino, Hassan S Dashti, Sherly X Li, Chloé Sarnowski, Anne E Justice, Misa Graff, Constantina Papoutsakis, Caren E Smith, George V Dedoussis, Rozenn N Lemaitre, Mary K Wojczynski, Satu Männistö, Julius S Ngwa, Minjung Kho, Tarunveer S Ahluwalia, Natalia Pervjakova, Denise K Houston, Claude Bouchard, Tao Huang, Marju Orho-Melander, Alexis C Frazier-Wood, Dennis O Mook-Kanamori, Louis Pérusse, Craig E Pennell, Paul S de Vries, Trudy Voortman, Olivia Li, Stavroula Kanoni, Lynda M Rose, Terho Lehtimäki, Jing Hua Zhao, Mary F Feitosa, Jian'an Luan, Nicola M McKeown, Jennifer A Smith, Torben Hansen, Niina Eklund, Mike A Nalls, Tuomo Rankinen, Jinyan Huang, Dena G Hernandez, Christina-Alexandra Schulz, Ani Manichaikul, Ruifang Li-Gao, Marie-Claude Vohl, Carol A Wang, Frank JA van Rooij, Jean Shin, Ioanna P Kalafati, Felix Day, Paul M Ridker, Mika Kähönen, David S Siscovick, Claudia Langenberg, Wei Zhao, Arne Astrup, Paul Knekt, Melissa Garcia, DC Rao, Qibin Qi, Luigi Ferrucci, Ulrika Ericson, John Blangero, Albert Hofman, Zdenka Pausova, Vera Mikkilä, Nick J Wareham, Sharon LR Kardia, Oluf Pedersen, Antti Jula, Joanne E Curran, M Carola Zillikens, Jorma S Viikari, Nita G Forouhi, José M Ordovás, John C Lieske, Harri Rissanen, André G Uitterlinden, Olli T Raitakari, Jessica C Kiefte-de Jong, Josée Dupuis, Jerome I Rotter, Kari E North, Robert A Scott, Michael A Province, Markus Perola, L Adrienne Cupples, Stephen T Turner, Thorkild IA Sørensen, Veikko Salomaa, Yongmei Liu, Yun J Sung, Lu Qi, Stefania Bandinelli, Stephen S Rich, Renée de Mutsert, Angelo Tremblay, Wendy H Oddy, Oscar H Franco, Tomas Paus, Jose C Florez, Panos Deloukas, Leo-Pekka Lyytikäinen, Daniel I Chasman, Audrey Y Chu, Toshiko Tanaka
Sep 19, 2018
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two...
Aged aging Alpha-Ketoglutarate-Dependent Dioxygenase FTO Cohort Studies Energy Intake Female Fibroblast Growth Factors Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomics Genotype Heart Diseases Humans Male Membrane Proteins Middle Aged nutrients obesity Polymorphism Single Nucleotide Receptors Retinoic Acid White People
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Amit Sud, Hauke Thomsen, Giulia Orlando, Asta Försti, Philip J Law, Peter Broderick, Rosie Cooke, Fadi Hariri, Tomi Pastinen, Douglas F Easton, Paul DP Pharoah, Alison M Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Daniele Campa, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Elke Pogge von Strandmann, Anthony J Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S Houlston
Nov 21, 2018
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults
Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth JF Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, Nilesh J Samani, UK Biobank CardioMetabolic Consortium CHD working group
Nov 22, 2018
BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because...
Coronary Artery Disease genomic risk prediction Primary Prevention Coronary Artery Disease Female Genome-Wide Association Study Genomics Humans Male Mass Screening Middle Aged Multifactorial Inheritance Predictive Value of Tests Primary Prevention Research Design Risk Assessment Risk Factors United Kingdom
Genetic determinants of risk in pulmonary arterial hypertension
Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe GN Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium
Jan 08, 2019
BACKGROUND: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for...
Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotyping Techniques HLA-DP alpha-Chains HLA-DP beta-Chains Humans Male Middle Aged Polymorphism Single Nucleotide pulmonary arterial hypertension Risk Assessment SOXF Transcription Factors Signal Transduction Survival Analysis
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul RHJ Timmers, Maarten van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain, Understanding Society Scientific Group
Jan 21, 2019
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function...
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
Manuel A Ferreira, Eric R Gamazon, Fares Al-Ejeh, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmaña, Daniel R Barnes, Daniel Barrowdale, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Ake Borg, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Trinidad Caldés, Maria A Caligo, Daniele Campa, Ian Campbell, Federico Canzian, Jonathan Carter, Brian D Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Hans Christiansen, Wendy K Chung, Kathleen BM Claes, Christine L Clarke, EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Miguel de la Hoya, Joe Dennis, Peter Devilee, Orland Diez, Thilo Dörk, Alison M Dunning, Miriam Dwek, Diana M Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A Fasching, Olivia Fletcher, Henrik Flyger, Eitan Friedman, Debra Frost, Marike Gabrielson, Manuela Gago-Dominguez, Patricia A Ganz, Susan M Gapstur, Judy Garber, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Wei He, Jane Heyworth, Frans BL Hogervorst, Antoinette Hollestelle, Robert N Hoover, John L Hopper, Peter J Hulick, Keith Humphreys, Evgeny N Imyanitov, ABCTB Investigators, HEBON Investigators, BCFR Investigators, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul A James, Ramunas Janavicius, Rachel C Jankowitz, Esther M John, Nichola Johnson, Vijai Joseph, Beth Y Karlan, Elza Khusnutdinova, Johanna I Kiiski, Yon-Dschun Ko, Michael E Jones, Irene Konstantopoulou, Vessela N Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Goska Leslie, Jenny Lester, Fabienne Lesueur, Sara Lindström, Jirong Long, Jennifer T Loud, Jan Lubiński, Enes Makalic, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna Marie Mulligan, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn C Nielsen, Liene Nikitina-Zake, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Håkan Olsson, Ana Osorio, Janos Papp, Tjoung-Won Park-Simon, Michael T Parsons, Inge Sokilde Pedersen, Ana Peixoto, Paolo Peterlongo, Paul DP Pharoah, Dijana Plaseska-Karanfilska, Bruce Poppe, Nadege Presneau, Paolo Radice, Johanna Rantala, Gad Rennert, Harvey A Risch, Emmanouil Saloustros, Kristin Sanden, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F Singer, Penny Soucy, Melissa C Southey, John J Spinelli, Amanda B Spurdle, Jennifer Stone, Anthony J Swerdlow, William J Tapper, Jack A Taylor, Manuel R Teixeira, Mary Beth Terry, Alex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Diana Torres, Thérèse Truong, Nadine Tung, Celine M Vachon, Christi J van Asperen, Ans Mw van den Ouweland, Elizabeth J van Rensburg, Ana Vega, Alessandra Viel, Qin Wang, Barbara Wappenschmidt, Jeffrey N Weitzel, Camilla Wendt, Robert Winqvist, Xiaohong R Yang, Drakoulis Yannoukakos, Argyrios Ziogas, Peter Kraft, Antonis C Antoniou, Wei Zheng, Douglas F Easton, Roger L Milne, Jonathan Beesley, Georgia Chenevix-Trench
Jan 29, 2019
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and...
Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Naomi Walsh, Han Zhang, Paula L Hyland, Qi Yang, Evelina Mocci, Mingfeng Zhang, Erica J Childs, Irene Collins, Zhaoming Wang, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Federico Canzian, Eric J Duell, Steven Gallinger, Graham G Giles, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Rayjean J Hung, Charles Kooperberg, Robert C Kurtz, Núria Malats, Loic Lemarchand, Rachel E Neale, Sara H Olson, Ghislaine Scelo, Xiao O Shu, Stephen K Van Den Eeden, Kala Visvanathan, Emily White, Wei Zheng, PanScan and PanC4 consortia, Demetrius Albanes, Gabriella Andreotti, Ana Babic, William R Bamlet, Sonja I Berndt, Ayelet Borgida, Marie-Christine Boutron-Ruault, Lauren Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Kari G Chaffee, Stephen Chanock, Sean Cleary, Michelle Cotterchio, Lenka Foretova, Charles Fuchs, J Michael M Gaziano, Edward Giovannucci, Michael Goggins, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Vladimir Janout, Eric A Klein, Robert C Kurtz, Daniel Laheru, I-Min Lee, Lingeng Lu, Núria Malats, Satu Mannisto, Roger L Milne, Ann L Oberg, Irene Orlow, Alpa V Patel, Ulrike Peters, Miquel Porta, Francisco X Real, Nathaniel Rothman, Howard D Sesso, Gianluca Severi, Debra Silverman, Oliver Strobel, Malin Sund, Mark D Thornquist, Geoffrey S Tobias, Jean Wactawski-Wende, Nick Wareham, Elisabete Weiderpass, Nicolas Wentzensen, William Wheeler, Herbert Yu, Anne Zeleniuch-Jacquotte, Peter Kraft, Donghui Li, Eric J Jacobs, Gloria M Petersen, Brian M Wolpin, Harvey A Risch, Laufey T Amundadottir, Kai Yu, Alison P Klein, Rachael Z Stolzenberg-Solomon
Feb 04, 2019
Serum magnesium levels and risk of coronary artery disease
Background. Observational studies have shown that serum magnesium levels are inversely associated risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomization study to...
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
Raffaele Ferrari, Yunpeng Wang, Jana Vandrovcova, Sebastian Guelfi, Aree Witeolar, Celeste M Karch, Andrew J Schork, Chun C Fan, James B Brewer, International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genomics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Parastoo Momeni, Gerard D Schellenberg, William P Dillon, Leo P Sugrue, Christopher P Hess, Jennifer S Yokoyama, Luke W Bonham, Gil D Rabinovici, Bruce L Miller, Ole A Andreassen, Anders M Dale, John Hardy, Rahul S Desikan
Feb 06, 2018
BACKGROUND: Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders...
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Jan 18, 2018
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population....
Animals Blood Glucose Body Fat Distribution Body Mass Index Fasting Female Gene Expression Regulation genetic variation Genome-Wide Association Study Genotype High-Throughput Nucleotide Sequencing Humans Insulin MicroRNAs Middle Aged Polymorphism Single Nucleotide RNA Messenger RNA Small Nucleolar RNA Small Untranslated Subcutaneous Fat
Genetic loci for retinal arteriolar microcirculation.
Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara EK Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus TVM de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Cornelia M van Duijn, Thor Aspelund, Gudny Eiriksdottir, Tamara B Harris, Fridbert Jonasson, Lenore J Launer, Wellcome Trust Case Control Consortium 2, John Attia, Paul N Baird, Stephen Harrap, Elizabeth G Holliday, Michael Inouye, Elena Rochtchina, Rodney J Scott, Ananth Viswanathan, Global BPGen Consortium, Guo Li, Nicholas L Smith, Kerri L Wiggins, Jane Z Kuo, Kent D Taylor, Alex W Hewitt, Nicholas G Martin, Grant W Montgomery, Cong Sun, Terri L Young, David A Mackey, Natalie R Van Zuydam, Alex SF Doney, Colin NA Palmer, Andrew D Morris, Jerome I Rotter, E Shyong Tai, Vilmundur Gudnason, Johannes R Vingerling, David S Siscovick, Jie Jin Wang, Tien Y Wong
Jan 23, 2018
Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a...
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
Kate Joanne Howell, Judith Kraiczy, Komal M Nayak, Marco Gasparetto, Alexander Ross, Claire Lee, Tim N Mak, Bon-Kyoung Koo, Nitin Kumar, Trevor Lawley, Anupam Sinha, Philip Rosenstiel, Robert Heuschkel, Oliver Stegle, Matthias Zilbauer
Jan 24, 2018
BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis....
epigenetics Gut microbiota Human Intestinal Organoids Intestinal Epithelium Adolescent Age Factors Biopsy Case-Control Studies Colitis Ulcerative Colon Sigmoid Crohn Disease DNA Methylation Diagnosis Differential England Epigenesis Genetic Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Profiling Genome-Wide Association Study Humans Ileum Intestinal Mucosa Male Organoids Predictive Value of Tests Prognosis Prospective Studies Ribotyping Time Factors Tissue Culture Techniques Transcription Genetic Transcriptome
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes
LA Lotta, RA Scott, SJ Sharp, S Burgess, J Luan, T Tillin, AF Schmidt, F Imamura, ID Stewart, JRB Perry, L Marney, A Koulman, ED Karoly, NG Forouhi, RJO Sjögren, E Näslund, JR Zierath, A Krook, DB Savage, JL Griffin, N Chaturvedi, AD Hingorani, K-T Khaw, I Barroso, MI McCarthy, S O'Rahilly, NJ Wareham, C Langenberg
Jan 18, 2017
Using ancestry-informative markers to identify fine structure across 15 populations of European origin.
Laura M Huckins, Vesna Boraska, Christopher S Franklin, James AB Floyd, Lorraine Southam, GCAN, WTCCC3, Patrick F Sullivan, Cynthia M Bulik, David A Collier, Chris Tyler-Smith, Eleftheria Zeggini, Ioanna Tachmazidou, GCAN, WTCCC3
Nov 17, 2017
The Wellcome Trust Case Control Consortium 3 anorexia nervosa genome-wide association scan includes 2907 cases from 15 different populations of European origin genotyped on the Illumina 670K chip. We compared methods for...
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
AE Justice, TW Winkler, MF Feitosa, M Graff, VA Fisher, K Young, L Barata, X Deng, J Czajkowski, D Hadley, JS Ngwa, TS Ahluwalia, AY Chu, NL Heard-Costa, E Lim, J Perez, JD Eicher, Z Kutalik, L Xue, A Mahajan, F Renström, J Wu, Q Qi, S Ahmad, T Alfred, N Amin, LF Bielak, A Bonnefond, J Bragg, G Cadby, M Chittani, S Coggeshall, T Corre, N Direk, J Eriksson, K Fischer, M Gorski, M Neergaard Harder, M Horikoshi, T Huang, JE Huffman, AU Jackson, JM Justesen, S Kanoni, L Kinnunen, ME Kleber, P Komulainen, M Kumari, U Lim, J Luan, L-P Lyytikäinen, M Mangino, A Manichaikul, J Marten, RPS Middelberg, M Müller-Nurasyid, P Navarro, L Pérusse, N Pervjakova, C Sarti, AV Smith, JA Smith, A Stančáková, RJ Strawbridge, HM Stringham, YJ Sung, T Tanaka, A Teumer, S Trompet, SW van der Laan, PJ van der Most, JV Van Vliet-Ostaptchouk, SL Vedantam, N Verweij, JM Vink, V Vitart, Y Wu, L Yengo, W Zhang, J Hua Zhao, ME Zimmermann, N Zubair, GR Abecasis, LS Adair, S Afaq, U Afzal, SJL Bakker, TM Bartz, J Beilby, RN Bergman, S Bergmann, R Biffar, J Blangero, E Boerwinkle, LL Bonnycastle, E Bottinger, D Braga, BM Buckley, S Buyske, H Campbell, JC Chambers, FS Collins, JE Curran, GJ de Borst, AJM de Craen, EJC de Geus, G Dedoussis, GE Delgado, HM den Ruijter, G Eiriksdottir, AL Eriksson, T Esko, JD Faul, I Ford, T Forrester, K Gertow, B Gigante, N Glorioso, J Gong, H Grallert, TB Grammer, N Grarup, S Haitjema, G Hallmans, A Hamsten, T Hansen, TB Harris, CA Hartman, M Hassinen, ND Hastie, AC Heath, D Hernandez, L Hindorff, LJ Hocking, M Hollensted, OL Holmen, G Homuth, J Jan Hottenga, J Huang, J Hung, N Hutri-Kähönen, E Ingelsson, AL James, J-O Jansson, M-R Jarvelin, MA Jhun, ME Jørgensen, M Juonala, M Kähönen, M Karlsson, HA Koistinen, I Kolcic, G Kolovou, C Kooperberg, BK Krämer, J Kuusisto, K Kvaløy, TA Lakka, C Langenberg, LJ Launer, K Leander, NR Lee, L Lind, CM Lindgren, A Linneberg, S Lobbens, M Loh, M Lorentzon, R Luben, G Lubke, A Ludolph-Donislawski, S Lupoli, PAF Madden, R Männikkö, P Marques-Vidal, NG Martin, CA McKenzie, B McKnight, D Mellström, C Menni, GW Montgomery, AB Musk, N Narisu, M Nauck, IM Nolte, AJ Oldehinkel, M Olden, KK Ong, S Padmanabhan, PA Peyser, C Pisinger, DJ Porteous, OT Raitakari, T Rankinen, DC Rao, LJ Rasmussen-Torvik, R Rawal, T Rice, PM Ridker, LM Rose, SA Bien, I Rudan, S Sanna, MA Sarzynski, N Sattar, K Savonen, D Schlessinger, S Scholtens, C Schurmann, RA Scott, B Sennblad, MA Siemelink, G Silbernagel, PE Slagboom, H Snieder, JA Staessen, DJ Stott, MA Swertz, AJ Swift, KD Taylor, BO Tayo, B Thorand, D Thuillier, J Tuomilehto, AG Uitterlinden, L Vandenput, M-C Vohl, H Völzke, JM Vonk, G Waeber, M Waldenberger, RGJ Westendorp, S Wild, G Willemsen, BHR Wolffenbuttel, A Wong, AF Wright, W Zhao, MC Zillikens, D Baldassarre, B Balkau, S Bandinelli, CA Böger, DI Boomsma, C Bouchard, M Bruinenberg, DI Chasman, Y-D Chen, PS Chines, RS Cooper, F Cucca, D Cusi, UD Faire, L Ferrucci, PW Franks, P Froguel, P Gordon-Larsen, H-J Grabe, V Gudnason, CA Haiman, C Hayward, K Hveem, AD Johnson, J Wouter Jukema, SLR Kardia, M Kivimaki, JS Kooner, D Kuh, M Laakso, T Lehtimäki, LL Marchand, W März, MI McCarthy, A Metspalu, AP Morris, C Ohlsson, LJ Palmer, G Pasterkamp, O Pedersen, A Peters, U Peters, O Polasek, BM Psaty, L Qi, R Rauramaa, BH Smith, TIA Sørensen, K Strauch, H Tiemeier, E Tremoli, P van der Harst, H Vestergaard, P Vollenweider, NJ Wareham, DR Weir, JB Whitfield, JF Wilson, J Tyrrell, TM Frayling, I Barroso, M Boehnke, P Deloukas, CS Fox, JN Hirschhorn, DJ Hunter, TD Spector, DP Strachan, CM van Duijn, IM Heid, KL Mohlke, J Marchini, RJF Loos, TO Kilpeläinen, C-T Liu, IB Borecki, KE North, LA Cupples
Jun 27, 2017
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