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Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.
Jessy Cartier, Thomas Smith, John P Thomson, Catherine M Rose, Batbayar Khulan, Andreas Heger, Richard R Meehan, Amanda J Drake
Sep 08, 2018
BACKGROUND: Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines...
DNA Methylation Early life programming epigenetic Germline transmission Glucocorticoids Histone modifications small RNA Animals Birth Weight DNA Methylation Dexamethasone Epigenesis Genetic Female Glucocorticoids Histone Code Male Maternal Exposure RNA Small Untranslated Rats Sprague-Dawley Spermatozoa