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Results: 18
Post-acute blood biomarkers and disease progression in traumatic brain injury.
Virginia FJ Newcombe, Nicholas J Ashton, Jussi P Posti, Ben Glocker, Anne Manktelow, Doris A Chatfield, Stefan Winzeck, Edward Needham, Marta M Correia, Guy B Williams, Joel Simrén, Riikka SK Takala, Ari J Katila, Henna Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K Menon
Apr 07, 2022
There is substantial interest in the potential for traumatic brain injury to result in progressive neurological deterioration. While blood biomarkers such as glial fibrillary acid protein (GFAP) and neurofilament light have been...
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury
Jussi P Posti, Riikka SK Takala, Hilkka Runtti, Virginia F Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzén, Henna Ala-Seppälä, Jonathan P Coles, Md Iftakher Hossain, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo
May 24, 2019
BACKGROUND: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI). OBJECTIVE: We investigated the relation of the GFAP and UCH-L1 levels to...
NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
Motaz M Fadul, Claire J Garwood, Rachel Waller, Navonna Garrett, Paul R Heath, Fiona E Matthews, Carol Brayne, Stephen B Wharton, Julie E Simpson
Jan 10, 2020
N-myc downstream regulated gene 2 (NDRG2) Ageing brain astrocyte Neurofibrillary Tangles Aged Aged 80 and over aging Alzheimer Disease Antigens CD Antigens Differentiation Myelomonocytic Astrocytes Brain DNA Damage Excitatory Amino Acid Transporter 2 Gene Expression Regulation Glial Fibrillary Acidic Protein Glutamate-Ammonia Ligase Humans Microglia Neurofibrillary Tangles Tumor Suppressor Proteins tau Proteins
Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.
Fay Probert, Tianrong Yeo, Yifan Zhou, Megan Sealey, Siddharth Arora, Jacqueline Palace, Timothy DW Claridge, Rainer Hillenbrand, Johanna Oechtering, Jens Kuhle, David Leppert, Daniel C Anthony
Jan 04, 2023
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury.
Iftakher Hossain, Mehrbod Mohammadian, Riikka SK Takala, Olli Tenovuo, Linnéa Lagerstedt, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Kaj Blennow, Jean-Charles Sanchez, Henrik Zetterberg, Jussi P Posti
Jan 09, 2019
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107...
Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures.
Animals Animals Newborn Calbindin 2 Cell Proliferation Cells Cultured Culture Media Conditioned Glial Fibrillary Acidic Protein Immunohistochemistry Mice Nerve Growth Factors Nerve Tissue Proteins Neuregulin-1 Neuroglia Neurons Olfactory Bulb Olfactory Mucosa Phenotype S100 Calcium Binding Protein G Spheroids Cellular Stem Cells Tubulin gamma-Aminobutyric Acid
The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.
astrocyte Fibronectin Multiple Sclerosis oligodendrocyte remyelination Animals Basic Helix-Loop-Helix Transcription Factors Cell Adhesion Cell Differentiation Cell Movement Cell Proliferation Demyelinating Diseases Disease Models Animal Fibronectins Glial Fibrillary Acidic Protein Homeobox Protein Nkx-2.2 Homeodomain Proteins Humans Ki-67 Antigen Lysophosphatidylcholines Mice Mice Knockout Nerve Regeneration Nerve Tissue Proteins Oligodendrocyte Transcription Factor 2 Oligodendroglia SOXB1 Transcription Factors Spinal Cord Stem Cells Transcription Factors Zebrafish Proteins
Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques.
M Mousavinejad, S Skidmore, FG Barone, P Tyers, V Pisupati, H Poptani, A Plagge, RA Barker, P Murray, A Taylor, CJ Hill
Apr 16, 2020
bioluminescence Dopaminergic neuron progenitor cells Human pluripotent stem cell Magnetic Resonance Imaging Non-invasive imaging Parkinson’s disease Animals Brain Carcinogenesis Cell Differentiation Cell Line Dopaminergic Neurons Ferric Compounds Genes Reporter Glial Fibrillary Acidic Protein Human Embryonic Stem Cells Humans Luminescent Measurements Magnetic Resonance Imaging Male Neural Stem Cells Neuroglia Particle Size Rats Stem Cell Transplantation
Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy.
Leonidas Chouliaras, Alan Thomas, Maura Malpetti, Paul Donaghy, Joseph Kane, Elijah Mak, George Savulich, Maria A Prats-Sedano, Amanda J Heslegrave, Henrik Zetterberg, Li Su, James Benedict Rowe, John Tiernan O'Brien
Jan 31, 2022
Alzheimer's Disease Dementia frontotemporal dementia LEWY BODY DEMENTIA MOVEMENT DISORDERS Alzheimer Disease Amyloid beta-Peptides Biomarkers Cognitive Dysfunction frontotemporal dementia Glial Fibrillary Acidic Protein Humans Lewy Body Disease Longitudinal Studies Neurodegenerative Diseases Supranuclear Palsy Progressive tau Proteins
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.
Carolin Heller, Martha S Foiani, Katrina Moore, Rhian Convery, Martina Bocchetta, Mollie Neason, David M Cash, David Thomas, Caroline V Greaves, Ione OC Woollacott, Rachelle Shafei, John C van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher R Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Sandro Sorbi, Markus Otto, Amanda J Heslegrave, Henrik Zetterberg, Jonathan D Rohrer, GENFI
Jan 27, 2020
BACKGROUND: There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
RSK Takala, JP Posti, H Runtti, VF Newcombe, JG Outtrim, AJ Katila, J Frantzén, H Ala-Seppälä, A Kyllönen, H-R Maanpää, J Tallus, MI Hossain, JP Coles, P Hutchinson, M van Gils, DK Menon, O Tenovuo
Dec 08, 2016
Biomarkers GFAP outcome Traumatic brain injury UCH-L1 Adolescent Adult Aged Area Under Curve Biomarkers Brain Injuries Female Glasgow Coma Scale Glial Fibrillary Acidic Protein Humans Injury Severity Score Logistic Models Male Middle Aged Predictive Value of Tests Prognosis Prospective Studies ROC Curve Ubiquitin Thiolesterase Young Adult
Blood biomarkers on admission in acute traumatic brain injury
Endre Czeiter, Krisztina Amrein, Benjamin Y Gravesteijn, Fiona Lecky, David K Menon, Stefania Mondello, Virginia FJ Newcombe, Sophie Richter, Ewout W Steyerberg, Thijs Vande Vyvere, Jan Verheyden, Haiyan Xu, Zhihui Yang, Andrew IR Maas, Kevin KW Wang, András Büki, CENTER-TBI Participants and Investigators
May 06, 2020
Biomarkers clinical decision rule Computerized tomography Diagnostic GFAP Injury severity serum Traumatic brain injury Aged Aged 80 and over Area Under Curve Biomarkers Brain Injuries Traumatic Female Glial Fibrillary Acidic Protein Humans Male Neurofilament Proteins Patient Admission Patient Care Planning Prospective Studies ROC Curve S100 Calcium Binding Protein beta Subunit Severity of Illness Index Tomography X-Ray Computed Ubiquitin Thiolesterase tau Proteins
Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury.
Correlation of Blood Biomarkers and Biomarker Panels with Traumatic Findings on Computed Tomography after Traumatic Brain Injury.
Jussi P Posti, Riikka SK Takala, Linnéa Lagerstedt, Alex M Dickens, Iftakher Hossain, Mehrbod Mohammadian, Henna Ala-Seppälä, Janek Frantzén, Mark van Gils, Peter J Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jussi Tallus, Kevin Hrusovsky, David H Wilson, Jessica Gill, Jean-Charles Sanchez, Olli Tenovuo, Henrik Zetterberg, Kaj Blennow
Feb 15, 2019
The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating computed tomography (CT)-negative and CT-positive patients with traumatic brain injury (TBI), utilizing highly...
Morphology of Radial Glial in Ependymal Layer With Ambystoma mexicanum
Justin Martinez
Jan 01, 0001
Regeneration in amphibians is a ubiquitous phenomenon, however, in mammals it is rare. Axolotls (Ambystoma mexicanum) have the ability to regenerate limbs, tails, retinas, and jaws throughout their lives. This exotic amphibian...
Published by: Ursinus College
Serial sampling of serum protein biomarkers for monitoring human traumatic brain injury dynamics
EP Thelin, FA Zeiler, A Ercole, S Mondello, A Büki, B-M Bellander, A Helmy, DK Menon, DW Nelson
Sep 06, 2017
Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
Lawrence R Shiow, Geraldine Favrais, Lucas Schirmer, Anne-Laure Schang, Sara Cipriani, Christian Andres, Jaclyn N Wright, Hiroko Nobuta, Bobbi Fleiss, Pierre Gressens, David H Rowitch
Dec 12, 2017
Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest of oligodendrocyte progenitor...
Cox2 astrocyte cerebral palsy Neuroinflammation oligodendrocyte prostaglandin white matter Animals Animals Newborn Astrocytes Cells Cultured Cyclooxygenase 2 Dinoprostone Female Fetus Gene Expression Regulation Developmental Glial Fibrillary Acidic Protein Humans Interleukin-1beta L-Lactate Dehydrogenase Male Mice Mice Inbred C57BL Mice Transgenic Oligodendroglia Rats Signal Transduction Spatial Memory white matter
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.
Florian T Merkle, Luis C Fuentealba, Timothy A Sanders, Lorenza Magno, Nicoletta Kessaris, Arturo Alvarez-Buylla
Oct 14, 2020
Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb....
Age Factors Animals Cerebral Ventricles Gene Expression Regulation Developmental Glial Fibrillary Acidic Protein Green Fluorescent Proteins Homeodomain Proteins Interneurons Kruppel-Like Transcription Factors Membrane Microdomains Mice Neural Stem Cells Neuroglia RNA Untranslated Transcription Factors Transduction Genetic Zinc Finger Protein GLI1