Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway
Joel P Giblett,
Richard G Axell,
Paul A White,
Sophie J Clarke,
Liam McCormick,
Philip A Read,
Johannes Reinhold,
Adam J Brown,
Michael O'Sullivan,
Nick EJ West,
David P Dutka,
Stephen P Hoole
Sep 29, 2016
BACKGROUND: Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels...