Search
Results: 5
A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms.
The lymphatic system is important for antigen presentation and immune surveillance. The lymphatic system in the brain was originally introduced by Giovanni Mascagni in 1787, while the rediscovery of it by Jonathan Kipnis and...
The glymphatic hypothesis
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood-brain barrier. It suggests that there is a circulation of fluid carrying...
Targeting Mitochondrial Metabolism in Neuroinflammation
The lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets....
immune metabolism MACROPHAGES Microglia Mitochondria Neuroinflammation progressive multiple sclerosis Central Nervous System Crotonates Dimethyl Fumarate Electron Transport Glymphatic System Humans Hydroxybutyrates Immunity Innate Metabolic Networks and Pathways Microglia Mitochondria Molecular Targeted Therapy Mononuclear Phagocyte System Multiple Sclerosis Chronic Progressive Neurodegenerative Diseases Nitriles Signal Transduction Stem Cell Transplantation Toluidines
Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury
Stéphanie Debette, Sabrina Schilling, Marie-Gabrielle Duperron, Susanna C Larsson, Hugh S Markus
Aug 02, 2019
IMPORTANCE: Covert vascular brain injury (VBI) is highly prevalent in community-dwelling older persons, but its clinical and therapeutic implications are debated. OBJECTIVE: To better understand the clinical significance of VBI...
Influence of Blood-Brain Barrier Integrity on Brain Protein Biomarker Clearance in Severe Traumatic Brain Injury
Caroline Lindblad, David W Nelson, Frederick A Zeiler, Ari Ercole, Per Hamid Ghatan, Henrik von Horn, Mårten Risling, Mikael Svensson, Denes V Agoston, Bo-Michael Bellander, Eric Peter Thelin
Jan 31, 2020
Brain protein biomarker clearance to blood in traumatic brain injury (TBI) is not fully understood. The aim of this study was to analyze the effect that a disrupted blood-brain barrier (BBB) had on biomarker clearance. Seventeen...