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Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.
Charles JM Bell, Yongliang Sun, Urszula M Nowak, Jan Clark, Sarah Howlett, Marcin L Pekalski, Xin Yang, Oliver Ast, Inja Waldhauer, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Christian Klein, Ralf J Hosse, Linda S Wicker, Laurence B Peterson
Oct 16, 2014
Autoimmunity Cytokine therapy Graft versus host disease IL-2 fusion proteins Regulatory T cells Animals Biomarkers CTLA-4 Antigen Dose-Response Relationship Drug Eosinophilia Female Forkhead Transcription Factors Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Count Macaca fascicularis Male Mice Mice Knockout Phenotype Phosphorylation Protein Binding Recombinant Fusion Proteins Recombinant Proteins STAT5 Transcription Factor Signal Transduction T-Lymphocyte Subsets T-Lymphocytes Regulatory