Search
Results: 11
Pulmonary retention of primed neutrophils
Charlotte Summers, Nanak R Singh, Jessica F White, Iain M Mackenzie, Andrew Johnston, Chandra Solanki, KK Balan, A Michael Peters, Edwin R Chilvers
Aug 14, 2014
ARDS Neutrophil Biology Blood Flow Velocity Cell Movement Erythrocytes Female Flow Cytometry Granulocyte-Macrophage Colony-Stimulating Factor Humans Indium Radioisotopes Male Middle Aged Neutrophils Platelet Activating Factor Radionuclide Imaging Respiratory Distress Syndrome Spirometry Technetium Time Factors
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Tomas Castro-Dopico, Aaron Fleming, Thomas W Dennison, John R Ferdinand, Katherine Harcourt, Benjamin J Stewart, Zaeem Cader, Zewen K Tuong, Chenzhi Jing, Laurence SC Lok, Rebeccah J Mathews, Anaïs Portet, Arthur Kaser, Simon Clare, Menna R Clatworthy
Jun 16, 2020
Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as...
GM-CSF anti-microbial defense Crosstalk inflammatory bowel disease innate lymphoid cells MACROPHAGES Wound Healing Animals Cell Polarity Citrobacter rodentium Colitis Enterobacteriaceae Infections Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunity Innate Inflammation Intestines Lymphocytes Macrophage Activation MACROPHAGES Mice Inbred C57BL Phenotype Wound Healing
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo CP van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre MJJ Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Jul 06, 2020
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF...
GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo.
Parmanand Singh, Silvia González-Ramos, Marina Mojena, César Eduardo Rosales-Mendoza, Hamed Emami, Jeffrey Swanson, Alex Morss, Zahi A Fayad, James HF Rudd, Jeffrey Gelfand, Marta Paz-García, Paloma Martín-Sanz, Lisardo Boscá, Ahmed Tawakol
Mar 10, 2016
18F-FDG-PET GM-CSF Glycolysis Inflammation macrophage Animals Arteritis Cells Cultured Fluorodeoxyglucose F18 Glycolysis Granulocyte-Macrophage Colony-Stimulating Factor Humans Image Enhancement MACROPHAGES Male Mice Positron-Emission Tomography Rabbits Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults.
Paul Milne, Venetia Bigley, Chris M Bacon, Antoine Néel, Naomi McGovern, Simon Bomken, Muzlifah Haniffa, Eli L Diamond, Benjamin H Durham, Johannes Visser, David Hunt, Harsha Gunawardena, Mac Macheta, Kenneth L McClain, Carl Allen, Omar Abdel-Wahab, Matthew Collin
Mar 18, 2019
Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. BRAFV600E mutation is the most common mutation in both conditions and also...
Adult Alleles Antigens CD Antigens CD1 Bone Marrow Cells Cell Differentiation Dendritic Cells Diagnosis Differential Erdheim-Chester Disease Female foam cells Gene Expression Glycoproteins Granulocyte-Macrophage Colony-Stimulating Factor Hematopoietic Stem Cells Histiocytosis Langerhans-Cell Humans Immunophenotyping Lectins C-Type Lipopolysaccharide Receptors Male Mannose-Binding Lectins Monocytes Mutation Proto-Oncogene Proteins B-raf Receptors Notch Transforming Growth Factor beta
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Richard P Hayhoe, Cristin G Print, Simon J Cook, Edwin R Chilvers
Jun 19, 2018
Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis...
Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Caspase 9 Cell Survival Gene Expression Regulation Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Inflammation Membrane Proteins Microscopy Confocal Models Biological Neutrophils Phenotype Pneumonia Proto-Oncogene Proteins Tumor Necrosis Factor-alpha
Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy
PR Kennedy, O Chazara, L Gardner, MA Ivarsson, LE Farrell, S Xiong, SE Hiby, F Colucci, AM Sharkey, A Moffett
Nov 24, 2016
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Jul 02, 2020
Apoptosis cytokine Proliferation Vascular smooth muscle Animals Apoptosis blood vessels Cell Proliferation Cells Cultured Cytokines Gene Expression Regulation Developmental Granulocyte-Macrophage Colony-Stimulating Factor Heparin-binding EGF-like Growth Factor Humans Interleukin-6 MAP Kinase Kinase 4 Mice Muscle Smooth Vascular Myocytes Smooth Muscle Oncogene Protein v-akt Signal Transduction Staurosporine fas Receptor p38 Mitogen-Activated Protein Kinases
Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation
Puja Mehta, Joanna C Porter, Jessica J Manson, John D Isaacs, Peter JM Openshaw, Iain B McInnes, Charlotte Summers, Rachel C Chambers
Jun 11, 2020
The COVID-19 pandemic is a global public health crisis, with considerable mortality and morbidity exerting pressure on health-care resources, including critical care. An excessive host inflammatory response in a subgroup of...
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Jil Sander, Susanne V Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, Anna C Aschenbrenner, Christoph Kreer, Thomas Quast, Alexander M Xu, Lisa M Schmidleithner, Heidi Theis, Lan Do Thi Huong, Hermi Rizal Bin Sumatoh, Mario AR Lauterbach, Jonas Schulte-Schrepping, Patrick Günther, Jia Xue, Kevin Baßler, Thomas Ulas, Kathrin Klee, Natalie Katzmarski, Stefanie Herresthal, Wolfgang Krebs, Bianca Martin, Eicke Latz, Kristian Händler, Michael Kraut, Waldemar Kolanus, Marc Beyer, Christine S Falk, Bettina Wiegmann, Sven Burgdorf, Nicholas A Melosh, Evan W Newell, Florent Ginhoux, Andreas Schlitzer, Joachim L Schultze
Mar 07, 2018
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and...
IL-4 IL-4 activated macrophages M(IL-4) NCOR2 activation human inflammatory dendritic cells inflammatory macrophages MACROPHAGES monocyte-derived dendritic cells Monocytes Cell Differentiation Cell Lineage Dendritic Cells Gene Expression Profiling Gene Expression Regulation Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunophenotyping Interleukin-4 Macrophage Activation Macrophage Colony-Stimulating Factor MACROPHAGES Monocytes Nuclear Receptor Co-Repressor 2 Primary Cell Culture Signal Transduction Time Factors Transcription Genetic
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E Schwab, Zainab Shahid, Michinori Shirano, Julia E Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Nov 16, 2022
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre...