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Results: 27
Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.
Laith Alexander, Philip LR Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Gemma J Cockcroft, Hannah F Clarke, Angela C Roberts
Dec 21, 2018
Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific...
PET imaging Anhedonia anterior cingulate area 25 Depression Ketamine Marmoset motivation Reward subgenual Anhedonia Animals blood pressure Callithrix Citalopram Conditioning Classical discrimination Psychological Disease Models Animal Excitatory Amino Acid Antagonists Female Fluorodeoxyglucose F18 Food Preferences Gyrus Cinguli Humans Ketamine Locomotion Male Proto-Oncogene Proteins c-fos Reward Selective Serotonin Reuptake Inhibitors Stress Psychological Sucrose
Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity.
Jessica Fritz, Jason Stretton, Adrian Dahl Askelund, Susanne Schweizer, Nicholas D Walsh, Bernet M Elzinga, Ian M Goodyer, Paul O Wilkinson, Anne-Laura van Harmelen
Feb 01, 2019
Neural substrates of cue reactivity and craving in Gambling Disorder
EH Limbrick-Oldfield, I Mick, RE Cocks, J McGonigle, SP Sharman, AP Goldstone, PRA Stokes, A Waldman, D Erritzoe, H Bowden-Jones, D Nutt, A Lingford-Hughes, L Clark
Jan 04, 2017
Shared alterations in resting-state brain connectivity in adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives.
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that often persists into adulthood with extensive negative consequences on quality of life. Despite emerging evidence indicating the...
Attention-deficit/hyperactivity disorder Default mode network dimensional Endophenotype functional connectivity resting state sustained attention Adolescent Adult Attention Deficit Disorder with Hyperactivity Brain Case-Control Studies Connectome Endophenotypes Family Female Frontal Lobe Gyrus Cinguli Humans Magnetic Resonance Imaging Male Middle Aged Nerve Net Neural Pathways Parietal Lobe Quality of life Young Adult
Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.
Cindy C Hagan, Julia ME Graham, Roger Tait, Barry Widmer, Adrienne O van Nieuwenhuizen, Cinly Ooi, Kirstie J Whitaker, Tiago Simas, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer, John Suckling
Apr 01, 2015
Sleep quality relates to emotional reactivity via intracortical myelination.
A good quality and amount of sleep are fundamental to preserve cognition and affect. New evidence also indicates that poor sleep is detrimental to brain myelination. In this study, we test the hypothesis that sleep quality...
Working memory training and brain structure and function in extremely preterm or extremely low birth weight children.
Claire E Kelly, Deanne K Thompson, Jian Chen, Elisha K Josev, Leona Pascoe, Megan M Spencer-Smith, Chris Adamson, Chiara Nosarti, Susan Gathercole, Gehan Roberts, Katherine J Lee, Lex W Doyle, Marc L Seal, Peter J Anderson
Nov 15, 2019
This study in children born extremely preterm (EP; <28 weeks' gestational age) or extremely low birth weight (ELBW; <1,000 g) investigated whether adaptive working memory training using Cogmed® is associated with structural...
Cogmed diffusion imaging functional imaging Magnetic Resonance Imaging MICROSTRUCTURE Preterm birth Brain Mapping Child Cognitive Remediation Female Gyrus Cinguli Humans Infant Extremely Low Birth Weight Infant Extremely Premature Infant Newborn Magnetic Resonance Imaging Male Memory Short-Term Neuronal Plasticity Outcome Assessment Health Care Parietal Lobe practice Psychological white matter
Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.
Laith Alexander, Christian M Wood, Philip LR Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Lauren McIver, Hannah F Clarke, Angela C Roberts
Oct 02, 2020
Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25)...
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus
Johann Steiner, Martin Walter, Tomasz Gos, Gilles J Guillemin, Hans-Gert Bernstein, Zoltán Sarnyai, Christian Mawrin, Ralf Brisch, Hendrik Bielau, Louise Meyer zu Schwabedissen, Bernhard Bogerts, Aye-Mu Myint
Sep 23, 2011
A bias towards natural rewards away from gambling cues in gamblers undergoing active treatment.
Casper Schmidt, Carsten Gleesborg, Hema Schmidt, Timo L Kvamme, Torben E Lund, Valerie Voon, Arne Møller
Apr 20, 2021
BACKGROUND: Disorders of substance and behavioral addiction are believed to be associated with a myopic bias towards the incentive salience of addiction-related cues away from general rewards in the environment. In non-treatment...
gambling disorder MID task orbitofrontal cortex Reward dissociation Striatum fMRI Adult Anticipation Psychological Brain Mapping Cognitive Behavioral Therapy Cues dorsolateral prefrontal cortex echo-planar imaging Erotica Female Gambling Gyrus Cinguli Humans Male motivation Reward Treatment Outcome Ventral Striatum Young Adult
Pain Control by Co-adaptive Learning in a Brain-Machine Interface.
Suyi Zhang, Wako Yoshida, Hiroaki Mano, Takufumi Yanagisawa, Flavia Mancini, Kazuhisa Shibata, Mitsuo Kawato, Ben Seymour
Jul 28, 2020
Innovation in the field of brain-machine interfacing offers a new approach to managing human pain. In principle, it should be possible to use brain activity to directly control a therapeutic intervention in an interactive...
PAG adaptive control brain-machine interface endogenous pain modulation fMRI Insula Pain pgACC real-time decoding uncertainty Brain Mapping Brain-Computer Interfaces Cerebral Cortex Electroencephalography Gyrus Cinguli learning Magnetic Resonance Imaging Neural Pathways Neurofeedback Pain Pain Management Periaqueductal Gray
Imaging suicidal thoughts and behaviors
Lianne Schmaal, Anne-Laura van Harmelen, Vasiliki Chatzi, Elizabeth TC Lippard, Yara J Toenders, Lynnette A Averill, Carolyn M Mazure, Hilary P Blumberg
Oct 28, 2019
Abnormal brain activation in excoriation (skin-picking) disorder
Anterior cingulate and medial prefrontal cortex response to systematically controlled tonal dissonance during passive music listening.
Fernando Bravo, Ian Cross, Christopher Hopkins, Nadia Gonzalez, Jorge Docampo, Claudio Bruno, Emmanuel A Stamatakis
Sep 23, 2019
Several studies have attempted to investigate how the brain codes emotional value when processing music of contrasting levels of dissonance; however, the lack of control over specific musical structural characteristics (i.e....
Task Encoding across the Multiple Demand Cortex Is Consistent with a Frontoparietal and Cingulo-Opercular Dual Networks Distinction.
UNLABELLED: Multiple-demand (MD) regions of the human brain show coactivation during many different kinds of task performance. Previous work based on resting-state functional magnetic resonance imaging (fMRI) has shown that MD...
COGNITIVE CONTROL dual networks Executive Function multiple demand Adolescent Adult Analysis of Variance Cerebral Cortex Executive Function Female Frontal Lobe Gyrus Cinguli Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Nerve Net Occipital Lobe Oxygen Parietal Lobe Psychomotor Performance Psychophysics Young Adult
Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy.
Yan Li, Chen Cheng Zhang, Kathrin Weidacker, Yingying Zhang, Naying He, Haiyan Jin, Weibo Chen, Valerie Voon, Richard AE Edden, Fuhua Yan
Aug 21, 2019
BACKGROUND: Obsessive-compulsive disorder (OCD) is a relatively common and disabling psychiatric disorder whose pathophysiology is incompletely understood. In this study, we utilized magnetic resonance spectroscopy (MRS) in an...
Brain responses to different types of salience in antipsychotic naïve first episode psychosis
Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murray
Oct 03, 2018
Abnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms has...
Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery
G Savulich, R Riccelli, L Passamonti, M Correia, JFW Deakin, R Elliott, RSA Flechais, AR Lingford-Hughes, J McGonigle, A Murphy, DJ Nutt, C Orban, LM Paterson, LJ Reed, DG Smith, J Suckling, R Tait, EM Taylor, BJ Sahakian, TW Robbins, KD Ersche, ICCAM Platform
Apr 10, 2017
Adult Adult Survivors of Child Adverse Events Alcoholism Amygdala Brain Case-Control Studies Cocaine-Related Disorders Cross-Over Studies Cues Double-Blind Method Female Functional Neuroimaging Gyrus Cinguli Hippocampus Humans Magnetic Resonance Imaging Male Middle Aged Naltrexone Narcotic Antagonists Neural Pathways Opioid-Related Disorders Prefrontal Cortex Substance-Related Disorders Young Adult
Extensive migration of young neurons into the infant human frontal lobe.
Mercedes F Paredes, David James, Sara Gil-Perotin, Hosung Kim, Jennifer A Cotter, Carissa Ng, Kadellyn Sandoval, David H Rowitch, Duan Xu, Patrick S McQuillen, Jose-Manuel Garcia-Verdugo, Eric J Huang, Arturo Alvarez-Buylla
Nov 21, 2017
The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in...
Default mode network connectivity during task execution.
Default mode network Finger opposition task functional connectivity Graph theory Hierarchical clustering Adult Brain Brain Mapping Cognition Data Interpretation Statistical Female Frontal Lobe Gyrus Cinguli Humans Magnetic Resonance Imaging Male Middle Aged Models Neurological Motor Activity Neural Pathways Neuropsychological Tests Psychomotor Performance Reaction Time Young Adult
Distinct Roles for the Anterior Cingulate and Dorsolateral Prefrontal Cortices During Conflict Between Abstract Rules
Network failures
fMRI Impulsivity monetary incentive delay stimulant drug dependence Adult Anticipation Psychological Brain Mapping Central Nervous System Stimulants Female Gyrus Cinguli Humans Impulsive Behavior Magnetic Resonance Imaging Male motivation Neostriatum Nerve Net personality Prefrontal Cortex Siblings Substance-Related Disorders Young Adult
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R Carta
Oct 10, 2022
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in...
Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.
Sufia S Rahman, Kevin Mulvihill, Christian M Wood, Shaun KL Quah, Nicole K Horst, Hannah F Clarke, Gemma J Cockcroft, Andrea M Santangelo, Angela C Roberts
Apr 15, 2021
Deniz Vatansever, Anne E Manktelow, Barbara J Sahakian, David K Menon, Emmanuel A Stamatakis
Dec 10, 2015
basal ganglia Cognitive flexibility Default mode network functional connectivity intra/extradimensional set-shifting Striatum Adult Basal Ganglia Brain Mapping Cognition Female Gyrus Cinguli Humans Magnetic Resonance Imaging Male Middle Aged Nerve Net Neural Pathways Neuropsychological Tests Parkinson Disease Schizophrenia
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