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Cover Image for VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer. View Article
VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer.
Andrew N Holding, Federico M Giorgi, Amanda Donnelly, Amy E Cullen, Sankari Nagarajan, Luke A Selth, Florian Markowetz
May 07, 2019
BACKGROUND: VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data. We apply...
Breast Cancer ChIP-seq dynamics ER GRHL2 H3K27ac Master regulator Network analysis P300 VULCAN Algorithms Breast Neoplasms DNA-Binding Proteins Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genetic Techniques Humans Transcription Factors
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