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CD4 mimetic Antibody epitope exposure human immunodeficiency virus nonhuman primate structural modification vaccine AIDS Vaccines Animals Antibodies Neutralizing Antibody-Dependent Cell Cytotoxicity CD4 Antigens CD4-Positive T-Lymphocytes Epitopes HIV Antibodies HIV Envelope Protein gp120 HIV-1 Immunoglobulin A Immunoglobulin G Macaca mulatta Vaccination env Gene Products Human Immunodeficiency Virus

To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific...

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AIDS Vaccines Animals Antibodies Neutralizing Chick Embryo Gene Products env Genetic Vectors HIV Antibodies HIV Antigens HIV Infections Macaca mulatta Poxviridae Promoter Regions Genetic vaccines Synthetic Viral Plaque Assay Viral Vaccines

Antibodies Antibody Affinity Antigen-Antibody Complex Antigens Benchmarking Datasets as Topic HIV Antibodies Internet Mutation Protein Engineering Software vaccines

The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging...

Antibodies Neutralizing Cell Line Tumor Epitopes HEK293 Cells HIV Antibodies HIV-1 Humans Immunoglobulin G Molecular Docking Simulation Molecular Dynamics Simulation Mutation Protein Binding Protein Conformation env Gene Products Human Immunodeficiency Virus

(6 max) Complete protection IgA IgG Passive immunization Rhesus monkey SHIV-C mucosal challenge Administration Intravenous Administration mucosal Animals Antibodies Monoclonal Antibodies Neutralizing HIV Antibodies HIV-1 Humans Immunity Cellular Immunity mucosal Immunization Passive Immunoglobulin A Immunoglobulin G Macaca mulatta Mucous Membrane RNA Viral Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus T-Lymphocytes

AIDS Vaccines Animals Antibody Formation CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes HIV Antibodies HIV-1 Immunization Secondary Macaca mulatta vaccines Synthetic

AIDS HIV-1 HIV-1 gp41 Membrane Fusion Protein Conformation Vaccine Development X-ray Scattering Amino Acid Sequence Animals Antibodies Neutralizing Antibody Affinity Female Guinea Pigs HIV Antibodies HIV Envelope Protein gp41 Humans Immune Sera Immunization Immunoglobulin G Molecular Sequence Data neutron diffraction Protein Structure Tertiary Proteolipids SCATTERING Small Angle

B-cell responses CD4 mimetic CD4 occluded T-cell responses human immunodeficiency virus nonhuman primates vaccines AIDS Vaccines Animals Antibodies Neutralizing Antibody-Dependent Cell Cytotoxicity B-Lymphocytes Binding Sites Antibody CD4 Antigens HIV Antibodies HIV-1 Macaca mulatta T-Lymphocytes Helper-Inducer Vaccination env Gene Products Human Immunodeficiency Virus

AIDS Vaccines Animals Antibodies Neutralizing Antibody-Dependent Cell Cytotoxicity DNA Primers HIV Antibodies HIV Antigens HIV-1 Interferon-gamma Male T-Lymphocytes Vaccination vaccines DNA gag Gene Products Human Immunodeficiency Virus