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The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Jan 02, 2019
UNLABELLED: Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation....
E3 ubiquitin ligase ER associated degradation HMGCR RNF145 Cell Biology Cholesterol gp78 human Animals CRISPR-Cas Systems Cholesterol Humans Hydroxymethylglutaryl CoA Reductases Membrane Proteins Mice Proteolysis Receptors Autocrine Motility Factor Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
Lipid traits and type 2 diabetes risk in African ancestry individuals
Opeyemi Soremekun, Ville Karhunen, Yiyan He, Skanda Rajasundaram, Bowen Liu, Apostolos Gkatzionis, Chisom Soremekun, Brenda Udosen, Hanan Musa, Sarah Silva, Christopher Kintu, Richard Mayanja, Mariam Nakabuye, Tafadzwa Machipisa, Amy Mason, Marijana Vujkovic, Verena Zuber, Mahmoud Soliman, Joseph Mugisha, Oyekanmi Nash, Pontiano Kaleebu, Moffat Nyirenda, Tinashe Chikowore, Dorothea Nitsch, Stephen Burgess, Dipender Gill, Segun Fatumo
Apr 24, 2022
BACKGROUND: Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus (T2DM). Numerous studies have sought to disentangle the causal relationship between dyslipidaemia and T2DM liability. However...