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The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Matthias M Schneider, Saurabh Gautam, Therese W Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M Miller, Victoria A Trinkaus, Quentin AE Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M Dobson, F Ulrich Hartl, Tuomas PJ Knowles
Sep 01, 2021
Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise...