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Results: 13
The effect of 2 mMol glutamine supplementation on HSP70 and TNF-α release by LPS stimulated blood from healthy children.
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H Horrocks, Magnus Kjaergaard, Sarah L Shammas, Sophie E Jackson, Christopher M Dobson, David Klenerman
Mar 13, 2018
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Matthias M Schneider, Saurabh Gautam, Therese W Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M Miller, Victoria A Trinkaus, Quentin AE Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M Dobson, F Ulrich Hartl, Tuomas PJ Knowles
Sep 01, 2021
Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise...
Lamin A/C modulates spatial organization and function of the Hsp70 gene locus via nuclear myosin I.
The structure-function relationship of the nucleus is tightly regulated, especially during heat shock. Typically, heat shock activates molecular chaperones that prevent protein misfolding and preserve genome integrity. However...
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
Francesco A Aprile, Paolo Arosio, Giuliana Fusco, Serene W Chen, Janet R Kumita, Anne Dhulesia, Paolo Tortora, Tuomas PJ Knowles, Michele Vendruscolo, Christopher M Dobson, Nunilo Cremades
Nov 13, 2017
Impact of severe hypoglycemia on the heat shock and related protein response.
Alexander S Atkin, Abu Saleh Md Moin, Manjula Nandakumar, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L Atkin, Alexandra E Butler
Aug 26, 2021
Heat shock proteins contribute to diabetes-induced complications and are affected by glycemic control. Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes...
Adult Aged Diabetes mellitus Type 2 Female HSP70 Heat-Shock Proteins HEAT-SHOCK PROTEINS Heat-Shock Response Humans Hypoglycemia Interferon-gamma Interleukins Intracellular Signaling Peptides and Proteins Male Middle Aged Molecular Chaperones Protein Serine-Threonine Kinases Proteome Receptor EphA2 Smad3 Protein Tumor Necrosis Factor-alpha Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
BiP Grp78 Biochemistry Calcium Cell Biology chemical biology Endoplasmic Reticulum None oligomerisation Adenosine Diphosphate Adenosine Triphosphatases Animals CHO Cells Calcium Cricetulus Crystallography X-Ray Drosophila Endoplasmic Reticulum Endoplasmic Reticulum Chaperone BiP Escherichia coli Flow Cytometry HSP70 Heat-Shock Proteins HEAT-SHOCK PROTEINS Immunoprecipitation Proteostasis Unfolded Protein Response
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
Marie Nicole Bongiovanni, Francesco Antonio Aprile, Pietro Sormanni, Michele Vendruscolo
Nov 12, 2018
Cooperative Assembly of Hsp70 Subdomain Clusters.
Maya A Wright, Francesco A Aprile, Mathias MJ Bellaiche, Thomas CT Michaels, Thomas Müller, Paolo Arosio, Michele Vendruscolo, Christopher M Dobson, Tuomas PJ Knowles
Sep 27, 2018
Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia.
Hong Wa Yung, Francesca Colleoni, Emilie Dommett, Tereza Cindrova-Davies, John Kingdom, Andrew J Murray, Graham J Burton
Jul 31, 2019
Preeclampsia (PE) is a dangerous complication of pregnancy, especially when it presents at <34 wk of gestation (PE < 34 wk). It is a major cause of maternal and fetal morbidity and mortality and also increases the risk of...
Mitochondria Preeclampsia Unfolded Protein Response Activating Transcription Factors Chaperonin 60 Eukaryotic Initiation Factor-2 Female HSP70 Heat-Shock Proteins Humans Mitochondria Mitochondrial Proteins Oxidative Phosphorylation pre-eclampsia Pregnancy Trophoblasts Unfolded Protein Response eIF-2 Kinase
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson's disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau...
Animals Biocatalysis Cell Line HSP70 Heat-Shock Proteins Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Models Animal Parkinson Disease Proteasome Endopeptidase Complex Protein Serine-Threonine Kinases Signal Transduction Substrate Specificity Transcription Genetic Ubiquitin Zebrafish ALPHA-SYNUCLEIN
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.
BiP/GRP78 Chinese Hamster Ovary (CHO) cells E. coli ERdj4/DNAJB9 ire1 Cell Biology endoplasmic reticulum (ER) Unfolded Protein Response (UPR) Animals CHO Cells Cricetinae Cricetulus Endoplasmic Reticulum Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Endoribonucleases Escherichia coli HSP40 Heat-Shock Proteins HSP70 Heat-Shock Proteins Humans Membrane Proteins Molecular Chaperones Protein Binding Protein Conformation Protein Multimerization Protein Serine-Threonine Kinases Unfolded Protein Response
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.
Niko Amin-Wetzel, Reuben A Saunders, Maarten J Kamphuis, Claudia Rato, Steffen Preissler, Heather P Harding, David Ron
Jun 08, 2018
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore protein-folding homeostasis. Unfolded proteins activate UPR signaling...
Allosteric Regulation Biological Feedback Endoplasmic Reticulum Fluorescence Resonance Energy Transfer HSP70 Heat-Shock Proteins Protein Dimerization Protein Folding Repressor Protein Stress Unfolded Protein Response Animals Cricetinae Endoplasmic Reticulum Endoplasmic Reticulum Chaperone BiP Endoribonucleases HSP40 Heat-Shock Proteins HEAT-SHOCK PROTEINS Humans Membrane Proteins Molecular Chaperones Protein Folding Protein Serine-Threonine Kinases Unfolded Protein Response