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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 30, 2021
Background
Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the...
genetic variation cardiac hypertrophy complex disease ribosome biogenesis ribosome profiling ribosomopathy Translational efficiency Spontaneously hypertensive rats (SHR) HXB/BXH rat recombinant inbred panel trans QTL mapping
Published by: Genome biology
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jun 28, 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 02, 2021
BACKGROUND: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of...
cardiac hypertrophy complex disease genetic variation HXB/BXH rat recombinant inbred panel ribosome biogenesis ribosome profiling ribosomopathy Spontaneously hypertensive rats (SHR) Translational efficiency trans QTL mapping Animals Cardiomegaly Gene Expression Profiling Gene Expression Regulation genetic variation Male Mice Mice Inbred C57BL Mice Knockout Myocardium Organelle Biogenesis Peptide Chain Initiation Translational Quantitative Trait Loci RNA Messenger RNA Small Nucleolar Rats Rats Inbred SHR Rats Transgenic Ribosomal Proteins Ribosomes Saccharomyces cerevisiae Sarcomeres