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Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia
David C.-Y. Lu, Rasiqh Wadud, Anke Hannemann, David C. Rees, John N. Brewin, John Stanley Gibson
Apr 02, 2021
Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca2+ and exposure of phosphatidylserine...